卵泡液氧化应激水平对辅助生殖治疗结局的影响
The Impact of Follicular Fluid Oxidative Stress Levels on the Outcomes of Assisted Reproductive Therapy.
作者信息
Chen Yu, Yang Jiahao, Zhang Ling
机构信息
Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, China.
出版信息
Antioxidants (Basel). 2023 Dec 14;12(12):2117. doi: 10.3390/antiox12122117.
Abstract
Oocyte quality is a pivotal determinant of assisted reproductive outcomes. The quality of oocytes is intricately linked to their developmental microenvironment, particularly the levels of oxidative stress within the follicular fluid. Oxidative stress levels in follicular fluid may have a substantial influence on oocyte health, thereby impacting the outcomes of ART procedures. This review meticulously explores the intricate relationship between oxidative stress in follicular fluid and ART outcomes. Furthermore, it delves into strategies aimed at ameliorating the oxidative stress status of follicular fluid, with the overarching goal of enhancing the overall efficacy of ART. This research endeavors to establish a robust foundation and provide valuable guidance for clinical treatment approaches, particularly in the context of infertile women, including those of advanced maternal age.
摘要
卵母细胞质量是辅助生殖结局的关键决定因素。卵母细胞的质量与其发育微环境密切相关，尤其是卵泡液中的氧化应激水平。卵泡液中的氧化应激水平可能对卵母细胞健康产生重大影响，从而影响辅助生殖技术（ART）程序的结局。本综述精心探讨了卵泡液中的氧化应激与ART结局之间的复杂关系。此外，还深入研究了旨在改善卵泡液氧化应激状态的策略，其总体目标是提高ART的整体疗效。本研究致力于建立坚实的基础，并为临床治疗方法提供有价值的指导，特别是在不孕女性（包括高龄产妇）的情况下。
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