Shin Jung-Won, Kang Taeuk, Swan Heather, Paik Kyungho, Huh Chang-Hun, Kim Hyun Jung
Department of Dermatology, Seoul National University Bundang Hospital, Gyeonggi, Korea; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
College of Natural Sciences, Sungshin Women’s University, Seoul, Korea.
Acta Derm Venereol. 2025 Jan 8;105:adv42248. doi: 10.2340/actadv.v105.42248.
Data on pregnancy outcomes in patients with alopecia areata (AA) are limited. The aim of this study is to determine the association between maternal AA and risk of adverse birth outcomes in children. A retrospective cohort study was conducted on 45,328 children born to mothers with AA and 4,703,253 controls born to mothers without AA using the Korean National Health Insurance Claims database from 2002 to 2016. Multivariate logistic regression analyses were performed to evaluate the association between maternal AA and the birth outcomes of their children. Infants born to mothers with AA exhibited a significantly higher risk of preterm birth (odds ratio [OR] 1.39, 95% CI 1.33-1.45; adjusted OR [aOR] 1.07, 95% CI 1.01-1.13), low birthweight (OR 1.36, 95% CI 1.30-1.42; aOR 1.11, 95% CI 1.05-1.17), and Caesarean section birth (OR 1.24, 95% CI 1.22-1.26; aOR 1.12, 95% CI 1.08-1.15) than controls. In addition, the risk of congenital malformations was also significantly higher in infants born to mothers with AA (OR 1.19, 95% CI 1.15-1.22; aOR 1.10, 95% CI 1.07-1.14), especially for malformations of the urinary (OR 1.33, 95% CI 1.19-1.48; aOR 1.16, 95% CI 1.04-1.29) and musculoskeletal (OR 1.19, 95% CI 1.12-1.27; aOR 1.12, 95% CI 1.05-1.19) systems, than controls. Maternal AA is associated with an increased risk of adverse birth outcomes in infants.
斑秃（AA）患者的妊娠结局数据有限。本研究的目的是确定母亲患斑秃与儿童不良出生结局风险之间的关联。利用2002年至2016年韩国国民健康保险索赔数据库，对45328名母亲患有斑秃的儿童和4703253名母亲未患斑秃的对照儿童进行了一项回顾性队列研究。进行多因素逻辑回归分析以评估母亲患斑秃与其子女出生结局之间的关联。与对照组相比，母亲患有斑秃的婴儿早产风险显著更高（比值比[OR]1.39，95%可信区间1.33 - 1.45；校正后OR[aOR]1.07，95%可信区间1.01 - 1.13）、低出生体重风险显著更高（OR 1.36，95%可信区间1.30 - 1.42；aOR 1.11，95%可信区间1.05 - 1.17）以及剖宫产出生风险显著更高（OR 1.24，95%可信区间1.22 - 1.26；aOR 1.12，95%可信区间1.08 - 1.15）。此外，母亲患有斑秃的婴儿先天性畸形风险也显著更高（OR 1.19，95%可信区间1.15 - 1.22；aOR 1.10，95%可信区间1.07 - 1.14），尤其是泌尿系统（OR 1.33，95%可信区间1.19 - 1.48；aOR 1.16，95%可信区间1.04 - 1.29）和肌肉骨骼系统（OR 1.19，95%可信区间1.12 - 1.27；aOR 1.12，95%可信区间1.05 - 1.19）的畸形。母亲患斑秃与婴儿不良出生结局风险增加有关。
