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[抑制性离子通道甘氨酸受体的研究进展]

[Advances in inhibitory ion channel glycine receptors].

作者信息

Pang Xu-Ke, Chen Si, Ma Xiang-Xian, Xu Yi-Nuo, Bai Wei-Jie, Fu Chong-Lei, Zou Gui-Chang

机构信息

Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.

Shandong Institute of Brain Science and Brain-inspired Research, Jinan 250117, China.

出版信息

Sheng Li Xue Bao. 2024 Dec 25;76(6):908-916.

Abstract

Glycine receptors (GlyRs) belong to the ligand-gated ion channel receptor superfamily and are widely distributed throughout the central nervous system. GlyRs are essential for maintaining visual, auditory, sensory and motor functions, and abnormalities in its structure and function can lead to various neurological disorders. This review aims to provide an extensive analysis of the structure, function and regulatory mechanisms of GlyRs, and evaluate its role in various central nervous system diseases. Ultimately, this review will provide theoretical support for the development of novel drugs specifically targeting GlyRs.

摘要

甘氨酸受体(GlyRs)属于配体门控离子通道受体超家族,广泛分布于整个中枢神经系统。甘氨酸受体对于维持视觉、听觉、感觉和运动功能至关重要,其结构和功能异常可导致各种神经疾病。本综述旨在对甘氨酸受体的结构、功能和调节机制进行广泛分析,并评估其在各种中枢神经系统疾病中的作用。最终,本综述将为开发特异性靶向甘氨酸受体的新型药物提供理论支持。

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