Li Xin, Tang Xiao, Qi Lianzhen, Chai Ruili
Department of Critical Care Medicine, the Second Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei, China.
Department of Anesthesia Critical Care Medicine, the Second Affiliated Hospital of Xingtai Medical College, Xingtai 054000, Hebei, China. Corresponding author: Chai Ruili, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2024 Dec;36(12):1305-1310. doi: 10.3760/cma.j.cn121430-20231211-01075.
To construct a risk prediction model for elderly severe patients with pneumonia infection, and analyze the prevention effect of 1M3S nursing plan under early warning mode.
Firstly, 180 elderly severe patients admitted to the department of intensive care unit (ICU) of the Second Affiliated Hospital of Xingtai Medical College from September 2020 to September 2021 were enrolled. Their clinical data were collected and retrospectively analyzed, and they were divided into infected group and non-infected group according to whether they developed severe pneumonia. The risk factors affecting severe pneumonia in elderly severe patients were screened by univariate and multifactorial analysis methods, and the risk prediction model was constructed. The predictive efficiency of the model was analyzed by receiver operator characteristic curve (ROC curve). Then the risk prediction model was applied to prospectively include 60 high-risk elderly patients with severe pneumonia admitted from December 2021 to August 2022. The patients were randomly divided into study group and control group by envelope method, with 30 cases in each group. Both groups were given routine nursing. On this basis, the study group adopted 1M3S nursing scheme [standardized nursing management (1M), improving nursing skills (S1), optimizing nursing service (S2), ensuring nursing safety (S3)] in the early warning mode for intervention. Acute physiology and chronic health evaluation II (APACHE II) and Murray lung injury score were compared between the two groups before intervention and 7 days after intervention.
Among 180 elderly severe patients, 34 cases were infected with pneumonia (18.89%). The proportion of patients with Glasgow coma scale (GCS) ≤ 8, duration of mechanical ventilation > 7 days, use of antibiotics, poor oral hygiene, hospital stay > 15 days and albumin ≤ 30 g/L in the infected group were significantly higher than those in the non-infected group. Multivariate Logistic regression analysis showed that duration of mechanical ventilation > 7 days, use of antibiotics, GCS score≤ 8, hospital stay > 15 days, albumin ≤ 30 g/L and poor oral hygiene were all independent risk factors for severe pneumonia in elderly severe patients. The odds ratio (OR) values were 3.180, 3.394, 1.108, 1.881, 1.517 and 2.512 (all P < 0.05). ROC curve analysis showed that the area under the ROC curve (AUC) of the prediction model to predict severe pneumonia in elderly severe patients was 0.838, 95% confidence interval was 0.748-0.927, sensitivity and specificity were 81.25% and 72.57%, respectively, and the Youden index was 0.538. (2) There was no significantly difference in general data between the study group and the control group, which was comparable. After intervention, the APACHE II score and Murray lung injury score of the two groups were significantly decreased, and the APACHE II score and Murray lung injury score of the study group were significantly lower than those of the control group (APACHE II score: 3.15±1.02 vs. 3.81±0.25, Murray lung injury score: 5.01±1.12 vs. 6.55±0.21, both P < 0.01).
There are many risk factors affecting the development of severe pneumonia in elderly severe patients. The risk prediction model based on duration of mechanical ventilation > 7 days, hospital stay > 15 days, GCS score≤ 8, albumin ≤ 30 g/L, poor oral hygiene and history of combined antibacterial use has high predictive efficacy. The intervention of 1M3S nursing scheme in the early warning mode can effectively reduce the risk of severe pneumonia in elderly severe patients, and significantly improve the pathophysiological status.
构建老年重症肺炎感染患者的风险预测模型,并分析预警模式下1M3S护理方案的预防效果。
首先,选取2020年9月至2021年9月在邢台医学高等专科学校第二附属医院重症监护病房(ICU)收治的180例老年重症患者。收集其临床资料并进行回顾性分析,根据是否发生重症肺炎分为感染组和非感染组。采用单因素和多因素分析方法筛选影响老年重症患者重症肺炎的危险因素,构建风险预测模型。通过受试者操作特征曲线(ROC曲线)分析模型的预测效能。然后将风险预测模型应用于前瞻性纳入的2021年12月至2022年8月收治的60例老年重症肺炎高危患者。采用信封法将患者随机分为研究组和对照组,每组30例。两组均给予常规护理。在此基础上,研究组采用1M3S护理方案[规范化护理管理(1M)、提升护理技能(S1)、优化护理服务(S2)、保障护理安全(S3)]在预警模式下进行干预。比较两组干预前及干预7天后的急性生理与慢性健康状况评分系统II(APACHE II)和默里肺损伤评分。
180例老年重症患者中,34例发生肺炎感染(18.89%)。感染组格拉斯哥昏迷量表(GCS)评分≤8分、机械通气时间>7天、使用抗生素、口腔卫生差、住院时间>15天及白蛋白≤30 g/L的患者比例均显著高于非感染组。多因素Logistic回归分析显示,机械通气时间>7天、使用抗生素、GCS评分≤8分、住院时间>15天、白蛋白≤30 g/L及口腔卫生差均为老年重症患者重症肺炎的独立危险因素。比值比(OR)值分别为3.180、3.394、1.108、1.881、1.517和2.512(均P<0.05)。ROC曲线分析显示,该预测模型预测老年重症患者重症肺炎的ROC曲线下面积(AUC)为0.838,95%置信区间为0.748~0.927,灵敏度和特异度分别为81.25%和72.57%,约登指数为0.538。(2)研究组与对照组一般资料比较,差异无统计学意义,具有可比性。干预后,两组APACHE II评分和默里肺损伤评分均显著降低,且研究组APACHE II评分和默里肺损伤评分均显著低于对照组(APACHE II评分:3.15±1.02比3.81±0.25,默里肺损伤评分:5.01±1.12比6.55±0.21,均P<0.01)。
影响老年重症患者重症肺炎发生的危险因素较多。基于机械通气时间>7天、住院时间>15天、GCS评分≤8分、白蛋白≤30 g/L、口腔卫生差及联合使用抗菌药物史构建的风险预测模型具有较高的预测效能。预警模式下1M3S护理方案的干预可有效降低老年重症患者发生重症肺炎的风险,并显著改善其病理生理状态。