社区居住队列中邻里劣势对心脏代谢健康和认知的影响。
Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community-dwelling cohort.
作者信息
Krishnamurthy Sudarshan, Lu Lingyi, Johnson Christian J, Baker Laura D, Leng Xiaoyan, Gaussoin Sarah A, Hughes Timothy M, Ma Da, Caban-Holt Allison, Byrd Goldie S, Craft Suzanne, Lockhart Samuel N, Bateman James R
机构信息
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Medical Center Boulevard Wake Forest University School of Medicine Winston-Salem North Carolina USA.
Department of Biostatistics and Data Science, Medical Center Boulevard Wake Forest University School of Medicine Winston-Salem North Carolina USA.
出版信息
Alzheimers Dement (Amst). 2024 Dec 6;16(4):e70021. doi: 10.1002/dad2.70021. eCollection 2024 Oct-Dec.
INTRODUCTION
Neighborhood disadvantage may be an important determinant of cardiometabolic health and cognitive aging. However, less is known about relationships among individuals with mild cognitive impairment (MCI).
METHODS
The objective of this study is to investigate the relationship between neighborhood disadvantage measured by national Area Deprivation Index (ADI) rank with measures of cardiometabolic health and cognition among Wake Forest (WF) Alzheimer's Disease Research Center (ADRC) participants, with and without MCI.
RESULTS
ADI was positively associated with blood pressure and cardiometabolic index (CMI), and negatively associated with global and Preclinical Alzheimer's Cognitive Composite (PACC5) scores, in cognitively unimpaired (CU) individuals. ADI was only positively associated with hemoglobin A1c (HbA1c) in MCI.
DISCUSSION
Neighborhood disadvantage is associated more strongly with measures of cardiometabolic health and cognition among CU individuals rather than MCI. These findings demonstrate a need for structural solutions to address social determinants of health in an attempt to reduce cardiometabolic and cognitive risks.
引言
邻里劣势可能是心脏代谢健康和认知衰老的重要决定因素。然而，对于轻度认知障碍（MCI）个体之间的关系了解较少。
方法
本研究的目的是调查由国家地区贫困指数（ADI）排名衡量的邻里劣势与维克森林（WF）阿尔茨海默病研究中心（ADRC）有或无MCI的参与者的心脏代谢健康和认知指标之间的关系。
结果
在认知未受损（CU）个体中，ADI与血压和心脏代谢指数（CMI）呈正相关，与总体和临床前阿尔茨海默病认知综合评分（PACC5）呈负相关。在MCI中，ADI仅与糖化血红蛋白（HbA1c）呈正相关。
讨论
邻里劣势与CU个体而非MCI个体的心脏代谢健康和认知指标的关联更强。这些发现表明需要结构性解决方案来解决健康的社会决定因素，以试图降低心脏代谢和认知风险。
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