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阿达木单抗用于治疗化脓性汗腺炎后发生泛发性脓疱型银屑病：一例报告

Eruption of Generalized Pustular Psoriasis Following Initiation of Adalimumab for Hidradenitis Suppurativa: A Case Report.

作者信息

Markeson Christopher D, Huang Simo, Hsu Sylvia

机构信息

Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.

出版信息

Cureus. 2024 Dec 9;16(12):e75402. doi: 10.7759/cureus.75402. eCollection 2024 Dec.

DOI:10.7759/cureus.75402
PMID:39781163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11710852/
Abstract

Rarely, tumor necrosis factor (TNF)-α inhibitors can paradoxically induce eruptions of psoriasis with generalized pustular psoriasis being among the least common presentations. We report a patient who presented with a generalized pustular eruption following adalimumab therapy for hidradenitis suppurativa (HS). The diagnosis of generalized pustular psoriasis was confirmed with a biopsy showing neutrophilic spongiosis and intraepidermal pustulosis. We discuss the role of tumor necrosis factor in psoriasis while describing possible mechanisms for this paradoxical reaction. Additionally, we discuss treatment options while considering the severity of the eruption and the underlying disease being treated with the tumor necrosis factor inhibitor.

摘要

罕见情况下，肿瘤坏死因子（TNF）-α抑制剂可反常地诱发银屑病皮疹，其中泛发性脓疱型银屑病是最不常见的表现之一。我们报告一例患者，其在接受阿达木单抗治疗化脓性汗腺炎（HS）后出现泛发性脓疱疹。活检显示嗜中性海绵形成和表皮内脓疱病，从而确诊为泛发性脓疱型银屑病。我们在描述这种反常反应的可能机制的同时，讨论肿瘤坏死因子在银屑病中的作用。此外，我们在考虑皮疹严重程度和正在接受肿瘤坏死因子抑制剂治疗的基础疾病的同时，讨论治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/5ef10d180add/cureus-0016-00000075402-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/6b66cb91850b/cureus-0016-00000075402-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/1c2675da60d8/cureus-0016-00000075402-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/7e2de49e0ea3/cureus-0016-00000075402-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/84a21593f113/cureus-0016-00000075402-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/0175ddc933e5/cureus-0016-00000075402-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/56bf8a6660c7/cureus-0016-00000075402-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/5ef10d180add/cureus-0016-00000075402-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/6b66cb91850b/cureus-0016-00000075402-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/1c2675da60d8/cureus-0016-00000075402-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/7e2de49e0ea3/cureus-0016-00000075402-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/84a21593f113/cureus-0016-00000075402-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/0175ddc933e5/cureus-0016-00000075402-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/56bf8a6660c7/cureus-0016-00000075402-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/11710852/5ef10d180add/cureus-0016-00000075402-i07.jpg

相似文献

[1]
Eruption of Generalized Pustular Psoriasis Following Initiation of Adalimumab for Hidradenitis Suppurativa: A Case Report.

Cureus. 2024-12-9

[2]
Adalimumab-Induced Paradoxical Psoriasis Treated with Biologics Targeting the IL-17/IL-23 Axis in Patients with Hidradenitis Suppurativa.

Dermatology. 2023

[3]
Paradoxical Induction of Psoriasis and Lichen Planus by Tumor Necrosis Factor-α Inhibitors.

Skinmed. 2015-10-1

[4]
Palmoplantar subcorneal pustular dermatosis following adalimumab therapy for rheumatoid arthritis.

Int J Dermatol. 2013-3-14

[5]
Generalized pustular psoriasis-like widespread eruption following COVID-19 infection in a patient with spondyloarthropathy on adalimumab.

Exp Dermatol. 2024-1

[6]
Secukinumab-induced paradoxical hidradenitis suppurativa.

Dermatol Ther. 2019-11-12

[7]
Concomitant psoriasis and hidradenitis suppurativa responsive to adalimumab therapy: A case series.

Indian J Dermatol Venereol Leprol. 2021

[8]
Paradoxical Hidradenitis Suppurativa in Patients Receiving TNF-α Inhibitors: Case Series, Systematic Review, and Case Meta-Analysis.

Dermatology. 2020

[9]
Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options.

Dermatol Ther (Heidelb). 2021-12

[10]
Paradoxical psoriasis induced by TNF-α blockade shows immunological features typical of the early phase of psoriasis development.

J Pathol Clin Res. 2020-1

本文引用的文献

[1]
TNF Inhibitor-Induced Psoriasis: Proposed Algorithm for Treatment and Management.

J Psoriasis Psoriatic Arthritis. 2019-4

[2]
Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon.

Front Immunol. 2018-11-28

[3]
Generalized Pustular Psoriasis Induced by Infliximab in a Patient With Inflammatory Bowel Disease.

J Cutan Med Surg. 2018-2-27

[4]
Tumor necrosis factor-α inhibitor-induced psoriasis: Systematic review of clinical features, histopathological findings, and management experience.

J Am Acad Dermatol. 2017-2

[5]
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J Am Acad Dermatol. 2012-5-18

[6]
Adalimumab (antitumour necrosis factor-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study.

Br J Dermatol. 2012-2

[7]
Drug focus: adalimumab in the treatment of moderate to severe psoriasis.

Biologics. 2007-6

[8]
Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases.

J Dermatolog Treat. 2009

[9]
Psoriasis and pustular dermatitis triggered by TNF-{alpha} inhibitors in patients with rheumatologic conditions.

Arch Dermatol. 2007-2

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