Alamoudi Anas, Alnabihi Ahmed N, Alsudais Ali Saleh, Almufarriji Naif, Batais Waleed T, Aldahlawi Abdulaziz Khalid, Altalhi Abdullah, Al-Dhibi Hassan A, Alakeely Adel G
Department of Ophthalmology, Jeddah Eye Hospital, Jeddah, Saudi Arabia.
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Clin Ophthalmol. 2025 Jan 3;19:1-9. doi: 10.2147/OPTH.S496737. eCollection 2025.
This systematic review and meta-analysis aimed to evaluate the safety and efficacy of combined laser and anti-VEGF therapy for (retinopathy of prematurity ROP), focusing on both structural and functional outcomes.
A comprehensive search was conducted in multiple databases to identify randomized controlled trials (RCTs) that investigated combination therapy for ROP. The PRISMA guidelines were followed. Data were extracted and analyzed using risk ratios and 95% confidence intervals (CIs). The Cochrane Risk of Bias tool was used to assess the risk of bias.
Three RCTs involving a total of 162 premature infants were included in the meta-analysis. Combination therapy of anti-VEGF and laser photocoagulation was compared with other interventions. The pooled analysis of favorable structural outcomes did not show a statistically significant difference between combination therapy with anti-VEGFs and laser therapy compared to the interventions in the control groups (P=0.25). The incidence of adverse events was comparable between the combination therapy group and other intervention groups.
This systematic review and meta-analysis suggest that risk ratio of combination therapy with anti-VEGF and laser for ROP is associated with favorable outcomes, albeit insignificant. The safety profile of combination therapy appears to be similar to other interventions. However, due to the limited number of included studies, further research is needed.
本系统评价和荟萃分析旨在评估联合激光和抗血管内皮生长因子（VEGF）治疗早产儿视网膜病变（ROP）的安全性和有效性，重点关注结构和功能结局。
在多个数据库中进行全面检索，以识别研究ROP联合治疗的随机对照试验（RCT）。遵循PRISMA指南。使用风险比和95%置信区间（CI）提取和分析数据。使用Cochrane偏倚风险工具评估偏倚风险。
荟萃分析纳入了3项RCT，共涉及162名早产儿。将抗VEGF与激光光凝的联合治疗与其他干预措施进行了比较。与对照组的干预措施相比，联合抗VEGF和激光治疗在有利结构结局方面的汇总分析未显示出统计学上的显著差异（P=0.25）。联合治疗组与其他干预组之间不良事件的发生率相当。
本系统评价和荟萃分析表明，抗VEGF与激光联合治疗ROP的风险比与良好结局相关，尽管不显著。联合治疗的安全性似乎与其他干预措施相似。然而，由于纳入研究数量有限，需要进一步研究。
