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生殖器汗孔角化症:一例报告及汗孔角化症发病机制与臀生殖器亚型的综述

Genital porokeratosis: A case report and review of pathogenesis and genitogluteal subtypes of porokeratosis.

作者信息

Hamm Camille, Lipson Jennifer

机构信息

Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

The Ottawa Hospital Division of Dermatology, Ottawa, ON, Canada.

出版信息

SAGE Open Med Case Rep. 2025 Jan 8;13:2050313X241311369. doi: 10.1177/2050313X241311369. eCollection 2025.

DOI:10.1177/2050313X241311369
PMID:39781378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11707782/
Abstract

Porokeratosis is a condition characterized by abnormal epidermal keratinization with a unique morphology of papules or plaques surrounded by a thread-like border of scale corresponding to the cornoid lamella on histology. Many established subtypes have been described; however, genitogluteal porokeratosis is a rare entity. We present the case of a 58-year-old male with pruritic reddish lesions affecting the genitals and thighs, diagnosed with genital porokeratosis. This case highlights features of this rare and diagnostically challenging subtype of porokeratosis.

摘要

汗孔角化症是一种以表皮角质化异常为特征的疾病,其丘疹或斑块具有独特的形态,周围有一条线状鳞屑边界,在组织学上对应于角样板层。已经描述了许多既定的亚型;然而,臀生殖器汗孔角化症是一种罕见的病症。我们报告一例58岁男性,其生殖器和大腿出现瘙痒性红色病变,诊断为生殖器汗孔角化症。该病例突出了这种罕见且诊断具有挑战性的汗孔角化症亚型的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7278/11707782/28078446663f/10.1177_2050313X241311369-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7278/11707782/bab6eab70048/10.1177_2050313X241311369-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7278/11707782/28078446663f/10.1177_2050313X241311369-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7278/11707782/bab6eab70048/10.1177_2050313X241311369-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7278/11707782/28078446663f/10.1177_2050313X241311369-fig2.jpg

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本文引用的文献

1
Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy.局部应用胆固醇/洛伐他汀治疗掌跖角化病:一种针对发病机制的治疗方法。
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2
Genitogluteal porokeratosis: a clinical review.生殖臀区汗孔角化症:临床综述
Clin Cosmet Investig Dermatol. 2018 May 1;11:219-229. doi: 10.2147/CCID.S143085. eCollection 2018.
3
Genital porokeratosis with amyloid deposition mimicking extramammary Paget disease.伴有淀粉样沉积的生殖器汗孔角化症,酷似乳腺外佩吉特病。
Clin Exp Dermatol. 2017 Apr;42(3):336-338. doi: 10.1111/ced.13034. Epub 2017 Jan 10.
4
Disseminated superficial porokeratosis involving the groin and genitalia in a 72-year-old immunocompetent man.一名72岁免疫功能正常男性的腹股沟和生殖器出现播散性浅表性汗孔角化症。
JAAD Case Rep. 2015 Jul 29;1(5):277-9. doi: 10.1016/j.jdcr.2015.06.011. eCollection 2015 Sep.
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Penoscrotal porokeratosis: A distinct entity.阴茎阴囊汗孔角化症:一种独特的病症。
Indian Dermatol Online J. 2015 Sep-Oct;6(5):339-41. doi: 10.4103/2229-5178.164487.
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Genital Porokeratosis: A Distinct Clinical Variant?生殖器汗孔角化症:一种独特的临床变体?
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8
Pruritic porokeratotic peno-scrotal plaques: porokeratosis or porokeratotic epidermal reaction pattern? A report of 10 cases.瘙痒性汗孔角化性阴茎阴囊斑块:汗孔角化症还是汗孔角化性表皮反应模式?10例报告
Indian J Dermatol Venereol Leprol. 2014 Jan-Feb;80(1):24-8. doi: 10.4103/0378-6323.125474.
9
Porokeratosis: present concepts.角化病:现有概念。
J Eur Acad Dermatol Venereol. 2012 Apr;26(4):404-12. doi: 10.1111/j.1468-3083.2011.04275.x. Epub 2011 Sep 20.
10
Genital porokeratosis: a series of 10 patients and review of the literature.生殖器汗孔角化症:10例患者系列报道及文献复习
Br J Dermatol. 2006 Aug;155(2):325-9. doi: 10.1111/j.1365-2133.2006.07295.x.