Srivastava Manoj Kumar, Singh Gaurav, Kodur Raveendra Ramamurthy, Yalamanchi Amulya
Department of General Medicine, Kashi Medicare, Varanasi-221001, Uttar Pradesh, India.
Department of General Medicine, Upendra Medicare, Varanasi-221001, Uttar Pradesh, India.
Int J Med Sci. 2025 Jan 1;22(2):383-397. doi: 10.7150/ijms.99958. eCollection 2025.
LN18178 is a standardized, synergistic combination of fruit rind and seed extracts, which has been reported to increase serum testosterone levels in young and aging males. The present 84-day randomized, double-blind, placebo-controlled study assessed the efficacy of LN18178 on the sexual function of aging male volunteers (age: 40-70 years; serum total testosterone: ≥ 300 ng/dL). The subjects with mild to moderate erectile dysfunction [5-item version of the International Index of Erectile Function (IIEF-5) scores 17-25] and low sexual desire (score < 3 on items 11 and 12 of IIEF) participated in this investigation. One hundred and twenty men were randomly allocated into either the LN18178 or placebo group (n=60); they took either 400 mg of LN18178 or a matched placebo capsule daily with breakfast. Post-trial, the LN18178-supplemented participants reported significant (P < 0.05) improvements in total and domain scores of the Derogatis Interview for Sexual Functioning-Self Reporting Male (DISF-SR-M) questionnaire, as well as substantial improvements in IIEF-5 (International Index of Erectile Function-5) and erection hardness scores (EHS). Comparative analysis also revealed significant improvements in the multi-dimensional fatigue inventory (MFI) and general health survey (GHS) scores. LN18178 supplementation substantially (P < 0.05) increased the six-minute walk distance and hand-grip strength compared to placebo. The participants' hemato-biochemical parameters, urinalysis, and vitals were within the normal range. LN18178 enhances sexual function, libido and improves psychological well-being, as well as neuromotor function and general well-being in aging males. LN18178 supplementation is safe and well tolerated by the participants.
LN18178是果皮和种子提取物的标准化协同组合，据报道它能提高年轻和老年男性的血清睾酮水平。目前这项为期84天的随机、双盲、安慰剂对照研究评估了LN18178对老年男性志愿者（年龄：40 - 70岁；血清总睾酮：≥300 ng/dL）性功能的疗效。患有轻度至中度勃起功能障碍[国际勃起功能指数（IIEF - 5）5项版本评分17 - 25]和性欲低下（IIEF第11项和第12项评分<3）的受试者参与了本研究。120名男性被随机分为LN18178组或安慰剂组（n = 60）；他们每天早餐时服用400毫克LN18178或匹配的安慰剂胶囊。试验后，补充LN18178的参与者报告称，性功能自我报告男性访谈量表（DISF - SR - M）问卷的总分和各领域得分有显著（P < 0.05）改善，国际勃起功能指数 - 5（IIEF - 5）和勃起硬度评分（EHS）也有大幅改善。对比分析还显示，多维疲劳量表（MFI）和一般健康调查（GHS）得分有显著改善。与安慰剂相比，补充LN18178显著（P < 0.05）增加了6分钟步行距离和握力。参与者的血液生化参数、尿液分析和生命体征均在正常范围内。LN18178可增强老年男性的性功能、性欲，改善心理健康以及神经运动功能和总体健康状况。补充LN18178是安全的，参与者耐受性良好。
