Thanh Tung Nguyen, Lee Yueh-Lun, Liu Wen-Te, Lin Yuan-Chien, Chang Jer-Hwa, Xuan Thao Huynh Nguyen, Ba Dung Hoang, Viet Trung Lam, Phan Chung Thuy Tran, Thi Hien Nguyen, Tsai Cheng-Yu, Lo Chen-Chen, Lo Kang, Ho Kin Fai, Chuang Kai-Jen, Chuang Hsiao-Chi
Otorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Department of Microbiology & Immunology College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ann Med. 2025 Dec;57(1):2448733. doi: 10.1080/07853890.2024.2448733. Epub 2025 Jan 9.
TWe investigated impacts of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM), relative humidity (RH), and temperature on sleep stages and arousal.
A cross-sectional analysis involving 8,611 participants was conducted at a sleep center in Taipei. We estimated individual-level exposure to RH, temperature, and PM over 1-day, 7-day, and 30-day periods. Linear regression models assessed the relationship between these environmental factors and sleep parameters across different seasons. Mediation analysis was used to explore PM, RH, and temperature roles in these relationships.
A 1% increase in RH over 1 and 7 days was associated with changes in non-rapid eye movement (NREM) sleep stages and increases in the arousal index across all seasons. A 1°C increase in temperature over similar periods led to increases in rapid eye movement (REM) sleep. During cold season, changes in RH and temperature were linked to variations in arousal and NREM sleep stages. In hot season, RH and temperature increases were correlated with changes in NREM sleep stages and arousal. Across all groups, a 1-μg/m³ increase in PM levels was associated with alterations in NREM and REM sleep stages and increases in the arousal index. We found PM levels mediated relationships between RH, temperature, and various sleep stages, particularly in cold season.
Lower RH and temperature, contributing to deep sleep reduction and increased arousal, were influenced by elevated PM exposure, especially during colder months. Enhancing environmental quality and reducing PM levels may lead to improved sleep quality.
我们研究了空气动力学直径小于2.5μm的颗粒物（PM）、相对湿度（RH）和温度对睡眠阶段及觉醒的影响。
在台北的一个睡眠中心对8611名参与者进行了横断面分析。我们估计了个体在1天、7天和30天期间暴露于相对湿度、温度和颗粒物的情况。线性回归模型评估了这些环境因素与不同季节睡眠参数之间的关系。中介分析用于探究颗粒物、相对湿度和温度在这些关系中的作用。
在所有季节中，1天和7天内相对湿度每增加1%，与非快速眼动（NREM）睡眠阶段的变化以及觉醒指数的增加有关。在相似时间段内温度每升高1°C，会导致快速眼动（REM）睡眠增加。在寒冷季节，相对湿度和温度的变化与觉醒及NREM睡眠阶段的变化有关。在炎热季节，相对湿度和温度的升高与NREM睡眠阶段及觉醒的变化相关。在所有组中，颗粒物水平每增加1μg/m³，与NREM和REM睡眠阶段的改变以及觉醒指数的增加有关。我们发现颗粒物水平介导了相对湿度、温度与各个睡眠阶段之间的关系，尤其是在寒冷季节。
较低的相对湿度和温度会导致深度睡眠减少和觉醒增加，这受到颗粒物暴露增加的影响，尤其是在较冷的月份。改善环境质量和降低颗粒物水平可能会提高睡眠质量。
