Watanabe T, Niki H
Brain Res. 1985 Jan 28;325(1-2):241-54. doi: 10.1016/0006-8993(85)90320-8.
Single unit activity was recorded from the hippocampus while Japanese monkeys (Macaca fuscata, n = 4) were performing a delayed response (DR) task. A total of 272 units showed an obvious change in discharge rate in relation to the events of the DR task. These 272 related units were classified into 6 groups: cue-light related units (n = 24), cue- and choice-light related units (n = 41), choice-light related units (n = 21), response-related units (n = 51), reward-error units (n = 17), and delay units (n = 118). Reward-error units contained reward-related and error-related units. Error-related units showed changes in firing after incorrect responses and/or after omission of reward on correct trials. It is noteworthy that 43.4% of the related units are delay units which showed increased or decreased firing preferentially during the delay period. Some units showed a differential firing pattern during cue or delay period depending on the spatial position of the cue. The results of the present study are interpreted as an experimental evidence for the involvement of the hippocampus in DR task.
在日本猕猴（猕猴属，n = 4）执行延迟反应（DR）任务时，记录了海马体的单神经元活动。共有272个神经元的放电率相对于DR任务的各个事件表现出明显变化。这272个相关神经元被分为6组：线索光相关神经元（n = 24）、线索和选择光相关神经元（n = 41）、选择光相关神经元（n = 21）、反应相关神经元（n = 51）、奖励误差神经元（n = 17）和延迟神经元（n = 118）。奖励误差神经元包含奖励相关和误差相关神经元。误差相关神经元在错误反应后和/或在正确试验中遗漏奖励后放电发生变化。值得注意的是，43.4%的相关神经元是延迟神经元，它们在延迟期优先表现出放电增加或减少。一些神经元在提示期或延迟期根据提示的空间位置表现出不同的放电模式。本研究结果被解释为海马体参与DR任务的实验证据。
