Benes F M, Paskevich P A, Davidson J, Domesick V B
Brain Res. 1985 Mar 11;329(1-2):265-73. doi: 10.1016/0006-8993(85)90532-3.
A morphometric analysis of the corpus striatum of rats chronically treated with haloperidol was performed at the light and electron microscopic levels. Although the density of striatal neurons was unchanged in the haloperidol-treated group, there was a small increase in neuronal size (13%). This change in cell size was paralleled by a trend towards larger dendrite calibres occurring in the drug-treated animals. The distribution curve for axon terminal size indicated that 12% of the overall population was shifted from a range with a median size of 0.8 micron 2 to one with 1.6 micron 2 in the drug-treated group. This increase in size of some striatal terminals was accompanied by a concomitant increase in numbers of their associated synaptic vesicles, resulting in a similar density of vesicles for both control and drug-treated animals.
在光学显微镜和电子显微镜水平上，对长期接受氟哌啶醇治疗的大鼠纹状体进行了形态计量分析。尽管氟哌啶醇治疗组纹状体神经元的密度没有变化，但神经元大小略有增加（13%）。细胞大小的这种变化与药物治疗动物中出现的树突直径变大的趋势相平行。轴突终末大小的分布曲线表明，在药物治疗组中，总体的12%从中位数大小为0.8平方微米的范围转移到了1.6平方微米的范围。一些纹状体终末大小的这种增加伴随着其相关突触小泡数量的相应增加，导致对照组和药物治疗组的小泡密度相似。
