Turrini Mauro, Otín-Gavín Jorge
Instituto de Políticas y Bienes Públicos (IPP), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Independent Researcher.
Sociol Health Illn. 2025 Jan;47(1):e13876. doi: 10.1111/1467-9566.13876.
Preimplantation Genetic Testing (PGT) is used to select in vitro embryos for distinct clinical contexts and purposes. PGT for monogenic conditions (PGT-M), also known as Preimplantation Genetic Diagnosis (PGD), enables the prevention of passing on a known genetic disorder to one's offspring. Conversely, PGT for aneuploidies (PGT-A), or Preimplantation Genetic Screening (PGS), is used to improve IVF success rates in fertility patients and increase confidence about the health outcomes of potential offspring. Using discourse analysis, we examine how Spanish fertility clinic digital platforms frame these techniques and their associated subjectivity processes. We find: first, an excessively unproblematic portrayal of experimental innovations such as PGT; second, a linguistic, semantic and clinical overlap between 'diagnosis' and 'screening', which increases the genetic responsibility of couples or women without known genetic conditions regarding their prospective children; and third, the use of genomics as a modulator of female fertility and as a means to control maternal age-related decline. Ultimately, this discourse positions PGT as a routine IVF component, serving as an assurance tool for both treatment success and the health of the potential baby. This narrative reflects the speculative turn in assisted reproduction, emphasising new forms of responsibility and choice of would-be mothers.
植入前基因检测（PGT）用于在不同临床背景和目的下选择体外胚胎。单基因疾病的植入前基因检测（PGT-M），也称为植入前基因诊断（PGD），能够防止将已知的遗传疾病传给后代。相反，非整倍体的植入前基因检测（PGT-A），即植入前基因筛查（PGS），用于提高生育患者体外受精的成功率，并增强对潜在后代健康状况的信心。通过话语分析，我们研究了西班牙生育诊所数字平台如何构建这些技术及其相关的主体性过程。我们发现：第一，对PGT等实验性创新的描述过于毫无问题；第二，“诊断”和“筛查”之间存在语言、语义和临床重叠，这增加了没有已知遗传疾病的夫妇或女性对其未来子女的遗传责任；第三，将基因组学用作女性生育能力的调节因素以及控制与母亲年龄相关的生育能力下降的手段。最终，这种话语将PGT定位为体外受精的常规组成部分，作为治疗成功和潜在婴儿健康的保证工具。这种叙述反映了辅助生殖中的投机转向，强调了未来母亲的新形式责任和选择。
