钙的剂量相关效应可增强L-色氨酸对肥胖患者肠道激素和能量摄入的影响。
Dose-related effects of calcium to enhance the effects of L-tryptophan on gut hormones and energy intake in obesity.
作者信息
Anjom-Shoae Javad, Fitzgerald Penelope C E, Horowitz Michael, Holst Jens J, Rehfeld Jens F, Veedfald Simon, Feinle-Bisset Christine
机构信息
Adelaide Medical School, University of Adelaide, Adelaide, Australia.
Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia.
出版信息
J Clin Endocrinol Metab. 2025 Jan 9. doi: 10.1210/clinem/dgaf008.
CONTEXT
In males of normal weight, intraduodenal administration of calcium enhances the effects of the amino acid, L-tryptophan (Trp), to suppress energy intake, associated with greater stimulation of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) secretion (key mechanisms underlying the regulation of pyloric motility and gastric emptying), but not gastrin or glucose-dependent insulinotropic polypeptide (GIP).
OBJECTIVE
Given the implications for the management of obesity, the current study evaluated the effects of calcium, when administered alone and in combination with Trp, on gut hormone secretion, antropyloroduodenal motility and energy intake in males with obesity.
METHODS
Fifteen males with obesity and without type 2 diabetes (mean±SD; age: 27±8 years; body mass index: 30±2 kg/m2; HbA1c: 5.3±0.2%), received 150-min intraduodenal infusions of 0, 500 or 1000 mg calcium, each combined with Trp (load: 0.1 kcal/min, known to have submaximal energy intake-suppressant effects) from t=75-150 min, on three separate occasions, in a randomized, double-blind, cross-over order. Plasma concentrations of gastrin, CCK, GIP, GLP-1, PYY, and pyloric pressures were measured during the infusions. Immediately post-infusion (t=150-180 min), energy intake at a standardized buffet-style lunch was quantified.
RESULTS
Calcium, in a dose of 1000 mg, stimulated GLP-1, PYY and pyloric pressures alone (all P<0.05), and enhanced the effects of Trp to stimulate CCK, GLP-1 and PYY (all P<0.05), associated with greater suppression of energy intake (P=0.01). Energy intake (R=-0.64; P=0.001) was inversely related to the dose of calcium, while plasma concentrations of CCK (R=0.44; P=0.05), GLP-1 (R=0.60; P=0.01) and PYY (R=0.83; P=0.01) were directly related.
CONCLUSIONS
Intraduodenal calcium enhances the effect of intraduodenal Trp to stimulate CCK, GLP-1 and PYY, and suppress energy intake, in males with obesity.
背景
在体重正常的男性中，十二指肠内给予钙可增强氨基酸L-色氨酸（Trp）抑制能量摄入的作用，这与胆囊收缩素（CCK）、胰高血糖素样肽-1（GLP-1）和酪酪肽（PYY）分泌受到更大刺激有关（这些是调节幽门运动和胃排空的关键机制），但对胃泌素或葡萄糖依赖性促胰岛素多肽（GIP）无影响。
目的
鉴于对肥胖管理的意义，本研究评估了单独给予钙以及钙与Trp联合使用时，对肥胖男性肠道激素分泌、胃幽门十二指肠运动和能量摄入的影响。
方法
15名无2型糖尿病的肥胖男性（均值±标准差；年龄：27±8岁；体重指数：30±2kg/m²；糖化血红蛋白：5.3±0.2%），在三个不同时间段，以随机、双盲、交叉顺序接受150分钟的十二指肠内输注，分别为0、500或1000mg钙，每种钙均与Trp联合使用（负荷：0.1千卡/分钟，已知具有次最大能量摄入抑制作用），输注时间为t = 75 - 150分钟。在输注过程中测量胃泌素、CCK、GIP、GLP-1、PYY的血浆浓度以及幽门压力。输注结束后立即（t = 150 - 180分钟），对标准化自助式午餐的能量摄入量进行量化。
结果
1000mg剂量的钙单独刺激了GLP-1、PYY和幽门压力（所有P<0.05），并增强了Trp刺激CCK、GLP-1和PYY的作用（所有P<0.05），同时对能量摄入的抑制作用更大（P = 0.01）。能量摄入量（R = -0.64；P = 0.001）与钙剂量呈负相关，而CCK（R = 0.44；P = 0.05）、GLP-1（R = 0.60；P = 0.01）和PYY（R = 0.83；P = 0.01）的血浆浓度与钙剂量呈正相关。
结论
十二指肠内给予钙可增强十二指肠内Trp刺激CCK、GLP-1和PYY以及抑制能量摄入的作用，在肥胖男性中。
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