Zanghì M, Morici V, Sequenzia S, Grillo S
Chir Ital. 1979 Feb;31(1):1-19.
After reviewing the more recent acquisitions on the physiology and pathophysiology of gastrin, the authors concentrate on situations of hypergastrinemia, which they divide into a hyperhydrochloric and a hypohydrochloric variety. Among the former, which they subdivide into preoperative and postoperative, the authors discuss problems of differential diagnosis versus peptic ulcers in patients so afflicted. To that end they propose diagnostic policies comprising among other instrumental and laboratory tests the study of gastric secretion, blood gastrin levels in basal conditions and after stimulation by a protein meal, BBS, secretin, and calcium. From analysis of the results of such tests they were able to find a precise nosographic placement for postoperative hypergastrinemia, and from there they arrived at surgical programs aiming to correct postoperative peptic ulcers on the basis of their etiology and pathogenesis.
在回顾了有关胃泌素生理学和病理生理学的最新研究成果后，作者们专注于高胃泌素血症的情况，他们将其分为高盐酸型和低盐酸型。在前者中，他们又细分为术前和术后两种情况，作者们讨论了这类患者与消化性溃疡的鉴别诊断问题。为此，他们提出了诊断策略，除了其他仪器和实验室检查外，还包括对胃分泌、基础状态下以及蛋白质餐、BBS、促胰液素和钙刺激后血胃泌素水平的研究。通过对这些检查结果的分析，他们能够为术后高胃泌素血症找到精确的疾病分类定位，并在此基础上制定旨在根据病因和发病机制纠正术后消化性溃疡的手术方案。
