Ko Jennifer K Y, Lam Mei Ting, Lam Kevin K W, Chan Tat On, Li Raymond H W, Ng Ernest H Y
Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Hong Kong, China.
J Assist Reprod Genet. 2025 Feb;42(2):509-523. doi: 10.1007/s10815-024-03326-z. Epub 2025 Jan 9.
To assess the association of serum vitamin D level and the live birth rate in women undergoing frozen embryo transfer (FET).
This is a retrospective cohort study involving 1489 infertile women who had frozen embryo transfer at two tertiary reproductive medicine centres from 2019 to 2021. Only the first frozen embryo transfer was included for women who had repeated transfers during the period. Archived serum samples taken at LH surge or before the start of progestogens for FET were analysed for 25(OH)D levels using mass spectrometry. The main outcome measure was the live birth rate. Vitamin D deficiency was defined as serum 25(OH)D < 50 nmol/l (< 20 ng/ml) based on the Endocrine Society Clinical Practice guidelines.
The median age was 36 (25th-75th percentile 34-38) years. 37.7% (561/1489) women had cleavage stage embryo transfer and 62.3% (928/1489) women had blastocyst transfer. When analysing the results based on the threshold in the Endocrine Society guideline of 50 nmol/l (20 ng/ml) for vitamin D deficiency, there were no statistically significant differences in the live birth rate in the vitamin D deficient and non-deficient groups [151/489 (30.9%) vs 341/998 (34.2%), OR 0.861, 95% CI 0.683-1.086 P = 0.205]. There were no statistically significant differences in the pregnancy rates, ongoing pregnancy rates, and miscarriage rates between the two groups.
Serum vitamin D is not associated with birth rate in women undergoing FET.
评估接受冻融胚胎移植（FET）的女性血清维生素D水平与活产率之间的关联。
这是一项回顾性队列研究，纳入了2019年至2021年在两家三级生殖医学中心接受冻融胚胎移植的1489名不孕女性。在此期间进行多次移植的女性仅纳入首次冻融胚胎移植。采用质谱分析法对促黄体生成素峰时或FET开始使用孕激素之前采集的存档血清样本进行25(OH)D水平分析。主要结局指标为活产率。根据内分泌学会临床实践指南，维生素D缺乏定义为血清25(OH)D＜50 nmol/l（＜20 ng/ml）。
中位年龄为36岁（第25-75百分位数为34-38岁）。37.7%（561/1489）的女性进行了卵裂期胚胎移植，62.3%（928/1489）的女性进行了囊胚移植。根据内分泌学会指南中维生素D缺乏阈值50 nmol/l（20 ng/ml）分析结果时，维生素D缺乏组和非缺乏组的活产率无统计学显著差异[151/489（30.9%）对341/998（34.2%），OR 0.861，95%CI 0.683-1.086，P = 0.205]。两组之间的妊娠率、持续妊娠率和流产率无统计学显著差异。
接受FET的女性血清维生素D水平与出生率无关。
