Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Academic Unit of Obstetrics and Gynecology, IRCCS AOU San Martino-IST, University of Genoa, Genova, Italy.
Gynecol Endocrinol. 2020 Sep;36(9):824-828. doi: 10.1080/09513590.2020.1712697. Epub 2020 Mar 3.
Do live birth rates (LBRs) differ in frozen cycles of women who received single versus double embryo transfer? Retrospective cohort study including women who underwent their first frozen embryo transfer (FET) in a tertiary referral University Hospital between 2009-2014. 3601 patients were included in the analysis with 1936 (53.8%) having a single embryo transfer (SET) and 1665 (46.2%) having a double embryo transfer (DET). Overall, 657/3601 (18.24%) had a live birth. LBR were similar between SET and DET either for cleavage [100/757 (13.1%) versus 153/1032 (14.8%), = .33] or blastocyst stage FET [256/1179 (21.7%) versus 148/633 (23.4%), = .4). Ongoing pregnancy rates were comparable between DET and SET [316/1665 (18.9%) versus 359/1936 (18.5%)]. Multiple delivery rates were significantly higher in women with DET compared to SET [53/316 (16.7%) versus 7/359 (1.9%), < .001]. Multivariate logistic regression analysis allowing adjustment for relevant confounders showed that the number of embryos transferred in the frozen cycle was not related to LBR. This is the largest study providing evidence that both SET and DET may result in similar LBR, albeit multiple pregnancy rates are significantly lower in case of SET. Therefore, SET should be the main strategy in women undergoing FET.
在接受单胚胎移植（SET）和双胚胎移植（DET）的女性的冷冻周期中，活产率（LBR）是否存在差异？这是一项回顾性队列研究，纳入了 2009 年至 2014 年期间在一家三级转诊大学医院接受首次冷冻胚胎移植（FET）的女性。共有 3601 名患者纳入分析，其中 1936 名（53.8%）接受 SET，1665 名（46.2%）接受 DET。总体而言，3601 名患者中有 657 名（18.24%）活产。SET 和 DET 的 LBR 相似，无论是卵裂期 [100/757（13.1%）与 153/1032（14.8%），=.33]还是囊胚期 FET [256/1179（21.7%）与 148/633（23.4%），=.4]。DET 和 SET 的持续妊娠率相当[1665 名中的 316 名（18.9%）与 1936 名中的 359 名（18.5%）]。DET 组的多胎分娩率明显高于 SET 组[316 名中的 53 名（16.7%）与 359 名中的 7 名（1.9%），<.001]。允许调整相关混杂因素的多变量逻辑回归分析表明，冷冻周期中移植的胚胎数量与 LBR 无关。这是一项最大规模的研究，提供了证据表明 SET 和 DET 均可导致相似的 LBR，尽管 SET 的多胎妊娠率明显较低。因此，SET 应成为接受 FET 的女性的主要策略。
