Zhou Chang, Qu Shaogang
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
ACS Chem Neurosci. 2025 Feb 5;16(3):284-291. doi: 10.1021/acschemneuro.4c00695. Epub 2025 Jan 9.
Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain, which seriously affects the quality of life of patients. Although there are various drug treatments available, many epilepsy patients still experience seizures with the effect of drugs and develop refractory epilepsy. The ketogenic diet can treat drug-refractory epilepsy by regulating the body's metabolism and can enhance the quality of life by improving their cognition, behavior, and sleep quality. However, there is no unified conclusion on the mechanism through which the ketogenic diet plays a therapeutic role in epilepsy. This article provides a review of the possible mechanisms of how the ketogenic diet exerts a protective effect on epilepsy.
癫痫是一种由大脑神经元异常放电引起的慢性神经系统疾病，严重影响患者的生活质量。尽管有多种药物治疗方法，但许多癫痫患者在药物作用下仍会发作，并发展为难治性癫痫。生酮饮食可以通过调节身体代谢来治疗药物难治性癫痫，并通过改善患者的认知、行为和睡眠质量来提高生活质量。然而，关于生酮饮食在癫痫中发挥治疗作用的机制尚无统一结论。本文综述了生酮饮食对癫痫发挥保护作用的可能机制。
