Pontes Ludmylla Cristina de Faria, Pimenta Isac Davidson Santiago Fernandes, de Medeiros Gidyenne Christine Bandeira Silva, Guillén-Martínez Daniel, Echevarria-Pérez Paloma, Piuvezam Grasiela, Capucho Helaine Carneiro
Faculty of Health Sciences, Postgraduation Program in Health Sciences, University of Brasilia, Brasilia, Brazil.
Postgraduation Program in Public Health, Federal University of Rio Grande do Norte, Natal, Brazil.
PLoS One. 2025 Jan 9;20(1):e0314201. doi: 10.1371/journal.pone.0314201. eCollection 2025.
Unplanned extubation (UPE), defined as accidental removal of the endotracheal tube during mechanical ventilation or its replacement due to suspected obstruction or inadequate diameter, is considered the fourth most common adverse event in neonatal intensive care units (NICU). This study aimed to describe a systematic review and meta-analysis protocol that will identify and assess the effect of primary intervention measures designed to prevent UPE in NICU. A search will be carried out in the following databases: PubMed/Medline, EMBASE, Scopus, CINAHL, Cochrane Library, SciELO, and LILACS. Reviewers, in pairs and independently, will select the studies, perform data extraction and assess the methodological quality of the included studies using preestablished tools according to the type of study. The systematic review will provide evidence to present the main intervention measures used in the prevention of UPE during the care of critical neonatal patients. The systematic review and meta-analysis resulting from this protocol may provide important information regarding UPE in the neonatal population, which will help with decision-making and the implementation of safer clinical practices that focus on the reduction of adverse events, contributing to the improvement of service management and the safety of neonatal patients.
非计划性拔管（UPE）被定义为在机械通气期间气管内导管意外拔除，或因怀疑导管阻塞或管径不足而进行更换，它被认为是新生儿重症监护病房（NICU）中第四常见的不良事件。本研究旨在描述一项系统评价和荟萃分析方案，该方案将识别和评估旨在预防NICU中UPE的主要干预措施的效果。将在以下数据库中进行检索：PubMed/Medline、EMBASE、Scopus、CINAHL、Cochrane图书馆、SciELO和LILACS。评审人员将成对且独立地选择研究、进行数据提取，并根据研究类型使用预先建立的工具评估纳入研究的方法学质量。该系统评价将提供证据，以呈现预防危重新生儿患者护理期间UPE所使用的主要干预措施。由该方案产生的系统评价和荟萃分析可能会提供有关新生儿人群中UPE的重要信息，这将有助于决策制定以及实施更安全的临床实践，这些实践侧重于减少不良事件，有助于改善服务管理和新生儿患者的安全。
