中国儿童代谢功能障碍相关脂肪性肝病与亚临床心血管指标的纵向关联
Longitudinal Associations Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Subclinical Cardiovascular Measures in Chinese Children.
作者信息
Qiao Yanan, Yang Lili, Yang Hui, Zheng Miaobing, Zhao Min, Xi Bo
机构信息
Department of Epidemiology/Department of Maternal, Child and Adolescent Health, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
出版信息
Am J Gastroenterol. 2024 Dec 31;120(6):1395-1399. doi: 10.14309/ajg.0000000000003278.
INTRODUCTION
The clinical utility of metabolic dysfunction-associated steatotic liver disease (MASLD) in predicting subsequent subclinical cardiovascular damages in pediatric population remains poorly understood.
METHODS
Data on 1,161 Chinese children aged 10-15 years were used to assess the longitudinal associations of MASLD with subsequent subclinical cardiovascular measures.
RESULTS
Compared with relatively healthy children, children with MASLD had abnormal vascular and cardiac structures, along with reduced cardiac diastolic function at the 2-year follow-up. In addition, children with MASLD had a significantly increased risk of high carotid intima-media thickness and left ventricular hypertrophy.
DISCUSSION
These findings support the clinical utility of MASLD in predicting the development of subclinical cardiovascular damages in childhood.
引言
代谢功能障碍相关脂肪性肝病（MASLD）在预测儿科人群随后发生的亚临床心血管损害方面的临床效用仍知之甚少。
方法
使用1161名10至15岁中国儿童的数据来评估MASLD与随后亚临床心血管指标之间的纵向关联。
结果
与相对健康的儿童相比，患有MASLD的儿童在2年随访时血管和心脏结构异常，同时心脏舒张功能降低。此外，患有MASLD的儿童发生高颈动脉内膜中层厚度和左心室肥厚的风险显著增加。
讨论
这些发现支持MASLD在预测儿童亚临床心血管损害发展方面的临床效用。
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