Dominguez-Riscart Jesus, Triviño-García Adrián, Sanchez-Toscano Esteban, Larran-Escandón Laura, Mateo-Gavira Isabel, Aguilar-Diosdado Manuel, de Mier-Morales Miguel
Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, 11009 Cádiz, Spain; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar, University Hospital, 11009 Cádiz, Spain.
School of Medicine, University of Cádiz (UCA),11002 Cádiz, Spain.
Early Hum Dev. 2025 Feb;201:106190. doi: 10.1016/j.earlhumdev.2024.106190. Epub 2025 Jan 2.
Trans girls may initiate early puberty blockers once puberty has started in order to prevent the development of masculine secondary sexual characteristics. Depending on how early the puberty blockers are administered, voice may have reached a certain degree of development and have acquired typically male acoustic and phonetic parameters, which can cause discomfort and affect the adolescent's quality of life.
The aim of the present study was to (1) determine if there are differences in discomfort with the self-perceiver voice according to the moment of puberty block (PB), and (2) find a relation between vocal discomfort and variables such a voice phonetic/acoustic characteristics and self-perception of voice.
A cross-sectional study was carried out. Differences in vocal discomfort between a group of trans girls with early puberty block and a group with late puberty block were compared. The participants were given the Voice Handicap index (VHI-30) and the Trans Women Voice Questionnaire (TWVQ) to assess vocal discomfort. In the same way, their anthropometric, clinical and vocal data, such as FO, were collected. The Kruskal-Wallis test was used to compare the differences in the TWVQ punctuation according to the Tanner stage.
The value of the fundamental frequency (FO) was 71.5 Hz higher in the early puberty block group (p < 0.001). The total scores of the questionnaires are higher in the late puberty block group (37.5 points in the TWVQ and 26 points in the VHI-30, p < 0.001 in both cases) Vocal self-perception tends to be more feminine in users with early blocked puberty (p = 0.001). There is a negative correlation between FO and puberty block age (r = 0.669) as well as with the TWVQ score (r = 0.755).
Early puberty blockers seem to be related to lower score in TWVQ and VHI-30. It could represent less vocal discomfort in trans girls. Acute voice seem to be more frequent in early puberty blocked because Fundamental frequency are significantly higher.
跨性别女孩一旦青春期开始，可能会开始使用青春期阻滞剂，以防止男性第二性征的发育。根据青春期阻滞剂使用的早晚，嗓音可能已经达到一定程度的发育，并获得了典型的男性声学和语音参数，这可能会导致不适并影响青少年的生活质量。
本研究的目的是（1）根据青春期阻断（PB）的时间，确定自我感知嗓音的不适是否存在差异，以及（2）找出嗓音不适与诸如嗓音语音/声学特征和嗓音自我感知等变量之间的关系。
进行了一项横断面研究。比较了一组早期青春期阻断的跨性别女孩和一组晚期青春期阻断的跨性别女孩在嗓音不适方面的差异。参与者接受了嗓音障碍指数（VHI-30）和跨性别女性嗓音问卷（TWVQ）以评估嗓音不适。同样，收集了她们的人体测量、临床和嗓音数据，如基频（FO）。使用Kruskal-Wallis检验根据坦纳分期比较TWVQ评分的差异。
早期青春期阻断组的基频（FO）值高71.5赫兹（p<0.001）。晚期青春期阻断组问卷的总分更高（TWVQ中为37.5分，VHI-30中为26分，两种情况均p<0.001）。早期青春期阻断的使用者嗓音自我感知往往更女性化（p = 0.001）。FO与青春期阻断年龄（r = 0.669）以及TWVQ评分（r = 0.755）之间存在负相关。
早期青春期阻滞剂似乎与TWVQ和VHI-30得分较低有关。这可能意味着跨性别女孩的嗓音不适较少。由于基频明显更高，早期青春期阻断者急性嗓音似乎更频繁。
