Fu Ruiyu, Liu Jiawei, Ma Yongpeng, Li Hongbo, Hai Xiaoqin, Niu Jiaxiao, Guo Xiaoli, Di Xin
Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; Key Laboratory of Ningxia Minority Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China.
J Hazard Mater. 2025 Apr 5;487:137143. doi: 10.1016/j.jhazmat.2025.137143. Epub 2025 Jan 6.
Tetracyclines (TCs) residues pose a significant threat to the aquatic environment and human health, therefore this study aims to develop a simple, rapid, and sensitive TCs detection method. Herein, a dual-responsive gel probe (LDH-CES@N) was designed, consisting of the intercalation of graphene quantum dots into europium-doped layered double hydroxide (LDH). In the presence of TCs, the as-prepared probe exhibited dual emission fluorescence at 504 nm and 616 nm due to the synergistic effect of aggregation-induced emission and antenna effect. Meanwhile, the density functional theory was employed to validate the mechanism underlying TC-induced electron transfer from graphene quantum dots. The dual-signal response fluorescence probe has excellent detection ability of oxytetracycline, including a wide detection range (0-60 μM), low detection limit (0.145 μM), and rapid response time (120 s). Furthermore, combined with the smartphone, a portable and real-time detection platform was established for the visual detection of oxytetracycline in tap water and honey samples with desirable recovery rates (97.8 %-105.4 %). Therefore, this work provides a new strategy for fluorescence detection of trace pollutants, demonstrating considerable practical application potential.
四环素（TCs）残留对水生环境和人类健康构成重大威胁，因此本研究旨在开发一种简单、快速且灵敏的TCs检测方法。在此，设计了一种双响应凝胶探针（LDH-CES@N），它由石墨烯量子点插入铕掺杂层状双氢氧化物（LDH）组成。在TCs存在的情况下，由于聚集诱导发光和天线效应的协同作用，所制备的探针在504nm和616nm处呈现双发射荧光。同时，采用密度泛函理论验证了TCs诱导石墨烯量子点电子转移的机制。该双信号响应荧光探针对土霉素具有优异的检测能力，包括宽检测范围（0-60μM）、低检测限（0.145μM）和快速响应时间（120s）。此外，结合智能手机，建立了一个便携式实时检测平台，用于对自来水和蜂蜜样品中的土霉素进行可视化检测，回收率良好（97.8%-105.4%）。因此，这项工作为痕量污染物的荧光检测提供了一种新策略，具有相当大的实际应用潜力。
