• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

生物性别在大脑衰老过程中起着重要作用。

Biological sex matters in brain aging.

作者信息

Dubal Dena B, Murphy Coleen T, Suh Yousin, Benayoun Bérénice A

机构信息

Department of Neurology and Weill Institute for Neurosciences, University of California San Franciso, San Francisco, CA, USA; Bakar Aging Research Institute, University of California San Franciso, San Francisco, CA, USA.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

出版信息

Neuron. 2025 Jan 8;113(1):2-6. doi: 10.1016/j.neuron.2024.12.005.

DOI:10.1016/j.neuron.2024.12.005
PMID:39788086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12210274/
Abstract

Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance for human health. Unraveling and harnessing mechanistic etiologies of sex differences may reveal new diagnostics and therapeutics for the aging brain.

摘要

体内的每个细胞都有生物学性别。衰老研究的扩展以探究女性和男性特有的生物学特性,预示着人类健康领域的一项重大进展。揭示并利用性别差异的机制病因可能会为衰老大脑带来新的诊断方法和治疗手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8543/12210274/821ab048f5b7/nihms-2048946-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8543/12210274/821ab048f5b7/nihms-2048946-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8543/12210274/821ab048f5b7/nihms-2048946-f0001.jpg

相似文献

1
Biological sex matters in brain aging.生物性别在大脑衰老过程中起着重要作用。
Neuron. 2025 Jan 8;113(1):2-6. doi: 10.1016/j.neuron.2024.12.005.
2
A cross-species analysis of neuroanatomical covariance sex differences in humans and mice.人类和小鼠神经解剖协方差性别差异的跨物种分析。
Biol Sex Differ. 2025 Jul 1;16(1):47. doi: 10.1186/s13293-025-00728-1.
3
Differently different?: A commentary on the emerging social cognitive neuroscience of female autism.别样不同?:女性自闭症社会认知神经科学的新发展述评。
Biol Sex Differ. 2024 Jun 13;15(1):49. doi: 10.1186/s13293-024-00621-3.
4
Neurovascular mechanisms of cognitive aging: Sex-related differences in the average progression of arteriosclerosis, white matter atrophy, and cognitive decline.神经血管机制与认知老化:动脉硬化、脑白质萎缩和认知能力下降平均进展的性别差异。
Neurobiol Dis. 2024 Oct 15;201:106653. doi: 10.1016/j.nbd.2024.106653. Epub 2024 Aug 28.
5
Sex-specific behavioral changes in middle-aged mice.中年小鼠的性别特异性行为变化。
Sci Rep. 2025 Jul 1;15(1):21992. doi: 10.1038/s41598-025-05001-4.
6
Innovations in Skin and Soft Tissue Aging-A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes.皮肤和软组织老化的创新疗法——治疗方法和相关结果的系统文献回顾和市场分析。
Aesthetic Plast Surg. 2023 Aug;47(4):1609-1622. doi: 10.1007/s00266-023-03322-1. Epub 2023 May 8.
7
-Related Overgrowth Spectrum相关过度生长谱系
8
Functional ultrasound as a quantitative approach for measuring functional hyperemia in aging models.功能超声作为一种测量衰老模型中功能性充血的定量方法。
Neuroimage. 2025 Aug 1;316:121313. doi: 10.1016/j.neuroimage.2025.121313. Epub 2025 Jun 12.
9
Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men.降低男男性行为者中艾滋病毒性传播风险的行为干预措施。
Cochrane Database Syst Rev. 2008 Jul 16(3):CD001230. doi: 10.1002/14651858.CD001230.pub2.
10
[Biological Aging Affects the Rate of Cognitive Decline in Middle-aged and Elderly Populations: A Cohort Study Based on CHARLS].[生物衰老对中老年人群认知衰退速度的影响:基于中国健康与养老追踪调查(CHARLS)的队列研究]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Mar 20;56(2):470-477. doi: 10.12182/20250360203.

引用本文的文献

1
Sex and ethnicity in early-onset Alzheimer's disease biomarkers and global function.早发性阿尔茨海默病生物标志物与整体功能中的性别和种族因素
Alzheimers Dement (Amst). 2025 Aug 12;17(3):e70157. doi: 10.1002/dad2.70157. eCollection 2025 Jul-Sep.
2
Aging activates escape of the silent X chromosome in the female mouse hippocampus.衰老会激活雌性小鼠海马体中失活X染色体的逃逸。
Sci Adv. 2025 Mar 7;11(10):eads8169. doi: 10.1126/sciadv.ads8169. Epub 2025 Mar 5.

本文引用的文献

1
The maternal X chromosome affects cognition and brain ageing in female mice.母本X染色体影响雌性小鼠的认知和大脑衰老。
Nature. 2025 Feb;638(8049):152-159. doi: 10.1038/s41586-024-08457-y. Epub 2025 Jan 22.
2
Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.衰老和阿尔茨海默病认知弹性的性别差异。
Alzheimers Dement. 2024 Aug;20(8):5695-5719. doi: 10.1002/alz.13844. Epub 2024 Jul 5.
3
Male-specific behavioral and transcriptomic changes in aging neurons.衰老神经元中雄性特异性行为和转录组变化。
iScience. 2024 May 8;27(6):109910. doi: 10.1016/j.isci.2024.109910. eCollection 2024 Jun 21.
4
Male-female comparisons are powerful in biomedical research - don't abandon them.在生物医学研究中,男女对比作用显著——不要摒弃它们。
Nature. 2024 May;629(8010):37-40. doi: 10.1038/d41586-024-01205-2.
5
Sex differences in pharmacokinetics predict adverse drug reactions in women.性别差异对药代动力学的影响可预测女性的药物不良反应。
Biol Sex Differ. 2020 Jun 5;11(1):32. doi: 10.1186/s13293-020-00308-5.
6
Genetically heterogeneous mice exhibit a female survival advantage that is age- and site-specific: Results from a large multi-site study.基因异质性小鼠表现出一种雌性生存优势,这种优势具有年龄和部位特异性:一项大型多中心研究的结果。
Aging Cell. 2019 Jun;18(3):e12905. doi: 10.1111/acel.12905. Epub 2019 Feb 23.
7
Persistent metabolic youth in the aging female brain.衰老女性大脑中持续的代谢年轻化。
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255. doi: 10.1073/pnas.1815917116. Epub 2019 Feb 4.
8
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.种族/民族、性别与冠心病的表观遗传时钟分析
Genome Biol. 2016 Aug 11;17(1):171. doi: 10.1186/s13059-016-1030-0.
9
Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span.年龄、性别和APOE ε4对成年期记忆、脑结构及β淀粉样蛋白的影响。
JAMA Neurol. 2015 May;72(5):511-9. doi: 10.1001/jamaneurol.2014.4821.