Linking E. coli to fibrosis in Crohn's disease.

作者信息

Dehantschutter Ethan T, Taylor Cormac T

机构信息

The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland; UCD School of Medicine, University College Dublin, Dublin, Ireland.

出版信息

Cell Host Microbe. 2025 Jan 8;33(1):12-14. doi: 10.1016/j.chom.2024.12.011.

Intestinal fibrosis associated with Crohn's disease is a serious yet poorly understood clinical complication. In this issue of Cell Host & Microbe, Ahn and colleagues provide evidence that the adherent intestinal E. coli produced the metallophore yersiniabactin, which sequesters zinc to drive intestinal fibrosis in a HIF-1α-dependent manner.