实验室小鼠研究的基本资源和最佳实践。
Essential resources and best practices for laboratory mouse research.
作者信息
Haque Rosa, Song Aysenur Deniz, Lee Jongsun, Lee Seung-Jae V, Suh Jae Myoung
机构信息
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, South Korea.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
出版信息
Mol Cells. 2025 Feb;48(2):100178. doi: 10.1016/j.mocell.2025.100178. Epub 2025 Jan 7.
The laboratory mouse (Mus musculus) is the most widely used mammalian model organism in biomedical and life science research. This concise guide aims to provide essential information to assist researchers new to working with mice, covering topics such as mouse husbandry, maintenance, and available resources for obtaining mouse strains and associated data. Additionally, we discuss ethical considerations, emphasizing the 3Rs (replacement, reduction, and refinement) to ensure responsible and humane research practices.
实验小鼠（小家鼠）是生物医学和生命科学研究中使用最广泛的哺乳动物模式生物。本简明指南旨在提供基本信息，以帮助初次使用小鼠的研究人员，涵盖小鼠饲养、管理以及获取小鼠品系和相关数据的可用资源等主题。此外，我们还讨论了伦理考量，强调了3R原则（替代、减少和优化），以确保负责任和人道的研究实践。
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