Lu Mingxuan, Zhang Jiayao, Zhang Qi, Sun Jiyu, Zou Danni, Huang Jinyin, Liu Weicai
Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Prosthodontics, Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China.
Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China; Shanghai Changning Mental Health Center, Shanghai 200335, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111250. doi: 10.1016/j.pnpbp.2025.111250. Epub 2025 Jan 7.
Eating behavior stands as a fundamental determinant of animal survival and growth, intricately regulated by an amalgamation of internal and external stimuli. Coordinated movements of facial muscles and the mandible orchestrate prey capture and food processing, propelled by the allure of taste and rewarding food properties. Conversely, satiation, pain, aversion, negative emotion or perceived threats can precipitate the cessation or avoidance of eating activities. In recent years, the parasubthalamic nucleus (PSTN), located in the lateral hypothalamic area, has emerged as a focal point in feeding research. PSTN neurons assume pivotal roles within multiple feeding circuits, bridging central feeding centers with peripheral organs. They intricately modulate regulation of oral sensorimotor functions, hedonic feeding, appetite motivation and the processing of satiation and aversive signals, thereby orchestrating the initiation or termination of feeding behaviors. This review delves into the distinctive neuronal subpopulations within the PSTN and their associated neural networks, aiming to refine our comprehension of the neural underpinnings of feeding while also seeking to unearth more efficacious therapeutic avenues for feeding and eating disorders.
进食行为是动物生存和生长的基本决定因素，受到内部和外部刺激的复杂调节。面部肌肉和下颌的协调运动在味觉和美味食物特性的吸引下，精心安排猎物捕获和食物处理过程。相反，饱腹感、疼痛、厌恶、负面情绪或感知到的威胁会促使进食活动停止或避免。近年来，位于下丘脑外侧区的丘脑底旁核（PSTN）已成为进食研究的焦点。PSTN神经元在多个进食回路中发挥关键作用，连接中枢进食中心和外周器官。它们复杂地调节口腔感觉运动功能、享乐性进食、食欲动机以及饱腹感和厌恶信号的处理，从而协调进食行为的启动或终止。本综述深入探讨了PSTN内独特的神经元亚群及其相关神经网络，旨在深化我们对进食神经基础的理解，同时也寻求发掘更有效的进食和饮食障碍治疗途径。
