Luo Xiaoting, Liang Junyi, Lei Xue, Sun Fengqi, Gong Minghai, Liu Bin, Zhou Zhongguang
Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
The First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
Brain Res Bull. 2025 Feb;221:111198. doi: 10.1016/j.brainresbull.2025.111198. Epub 2025 Jan 7.
Alzheimer's disease (AD) stands as one of the most prevalent neurodegenerative disorders, characterized by a progressive decline in cognitive function, neuroinflammation, amyloid-beta (Aβ) plaques, and neurofibrillary tangles (NFTs). With the global aging population, the incidence of AD continues to rise, yet current therapeutic strategies remain limited in their ability to significantly alleviate cognitive impairments. Therefore, a deeper understanding of the molecular mechanisms underlying AD is imperative for the development of more effective treatments. In recent years, the transcription factor C/EBPβ has emerged as a pivotal regulator in several pathological processes of AD, including neuroinflammation, lipid metabolism, Aβ processing, and tau phosphorylation. Through intricate post-translational modifications, C/EBPβ modulates these processes and may influence the progression of AD on multiple fronts. This review systematically explores the multifaceted roles of C/EBPβ in the pathogenesis of AD, delving into its crucial involvement in neuroinflammation, Aβ production, tau pathology, and lipid metabolism dysregulation. Furthermore, we critically assess therapeutic strategies targeting C/EBPβ, examining the challenges and opportunities in regulating this factor. By synthesizing the latest research findings, we offer a more comprehensive understanding of the role of C/EBPβ in AD and discuss its potential as a therapeutic intervention target.
阿尔茨海默病（AD）是最常见的神经退行性疾病之一，其特征是认知功能进行性下降、神经炎症、β-淀粉样蛋白（Aβ）斑块和神经原纤维缠结（NFTs）。随着全球人口老龄化，AD的发病率持续上升，但目前的治疗策略在显著减轻认知障碍方面的能力仍然有限。因此，深入了解AD的分子机制对于开发更有效的治疗方法至关重要。近年来，转录因子C/EBPβ已成为AD若干病理过程中的关键调节因子，包括神经炎症、脂质代谢、Aβ加工和tau磷酸化。通过复杂的翻译后修饰，C/EBPβ调节这些过程，并可能在多个方面影响AD的进展。本综述系统地探讨了C/EBPβ在AD发病机制中的多方面作用，深入研究了其在神经炎症、Aβ产生、tau病理和脂质代谢失调中的关键参与。此外，我们批判性地评估了针对C/EBPβ的治疗策略，审视了调节该因子所面临的挑战和机遇。通过综合最新研究结果，我们对C/EBPβ在AD中的作用有了更全面的理解，并讨论了其作为治疗干预靶点的潜力。
