Carter Benjamin Alexander, Parker Victoria Elizabeth
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.
Curr Probl Cardiol. 2025 Mar;50(3):102980. doi: 10.1016/j.cpcardiol.2025.102980. Epub 2025 Jan 7.
The regulation of calcium signaling within cardiomyocytes is pivotal for maintaining cardiac function, with disruptions in sarcoplasmic reticulum (SR) calcium handling linked to various heart diseases. This review explores the emerging role of microRNAs (miRNAs) in modulating SR calcium dynamics, highlighting their influence on cardiomyocyte maturation, function, and disease progression. We present a comprehensive overview of the mechanisms by which specific miRNAs, such as miR-1, miR-24, and miR-22, regulate key components of calcium handling, including ryanodine receptors, SERCA, and NCX. Notably, we identify critical research gaps, particularly the inconsistent findings regarding miRNA expression in heart disease and the need for standardized experimental conditions. Furthermore, we emphasize the potential of miRNAs as therapeutic targets, given their ability to influence calcium handling pathways and cardiac remodeling. The review also discusses the challenges in translating miRNA research into clinical applications, including the need for safe and effective delivery methods. By synthesizing current knowledge and identifying areas for future investigation, this review aims to provide insights into the therapeutic potential of miRNAs in diagnosing and treating heart diseases, ultimately contributing to improved patient outcomes.
心肌细胞内钙信号的调节对于维持心脏功能至关重要，肌浆网（SR）钙处理的紊乱与多种心脏病相关。本综述探讨了微小RNA（miRNA）在调节SR钙动力学中的新作用，强调了它们对心肌细胞成熟、功能和疾病进展的影响。我们全面概述了特定miRNA（如miR-1、miR-24和miR-22）调节钙处理关键成分（包括兰尼碱受体、肌浆网钙ATP酶和钠钙交换体）的机制。值得注意的是，我们确定了关键的研究空白，特别是关于心脏病中miRNA表达的不一致发现以及对标准化实验条件的需求。此外，鉴于miRNA能够影响钙处理途径和心脏重塑，我们强调了它们作为治疗靶点的潜力。本综述还讨论了将miRNA研究转化为临床应用的挑战，包括对安全有效递送方法的需求。通过综合当前知识并确定未来研究领域，本综述旨在深入了解miRNA在诊断和治疗心脏病中的治疗潜力，最终有助于改善患者预后。
