Tao Qian, Liu Nian, Chen Jing, Wu Jie, Li Jie, Chen Xiang, Peng Cong
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha 410008.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Aug 28;49(8):1309-1315. doi: 10.11817/j.issn.1672-7347.2024.240389.
Ferroptosis is a unique form of cell death driven by iron-dependent lipid peroxidation, with regulatory mechanisms involving metabolic dysregulation and imbalance in redox systems. Ferroptosis is closely related to various immune cells in the tumor immune microenvironment, including both anti-tumor and pro-tumor immune cells, and it demonstrates significant potential in tumor immunotherapy. A systematic review of the regulatory mechanisms of ferroptosis and its relationship with immune cells can provide deeper insights into its application prospects in tumor immunotherapy.
铁死亡是一种由铁依赖性脂质过氧化驱动的独特细胞死亡形式，其调节机制涉及代谢失调和氧化还原系统失衡。铁死亡与肿瘤免疫微环境中的各种免疫细胞密切相关，包括抗肿瘤和促肿瘤免疫细胞，并且在肿瘤免疫治疗中显示出巨大潜力。对铁死亡的调节机制及其与免疫细胞的关系进行系统综述，可以更深入地了解其在肿瘤免疫治疗中的应用前景。
