Wintermann Gloria-Beatrice, Abraham Susanne, Peters Eva M J, Beissert Stefan, Weidner Kerstin
Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Department of Dermatology, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany.
Sci Rep. 2025 Jan 10;15(1):1553. doi: 10.1038/s41598-024-84794-2.
The Dermatology Life Quality Index (DLQI) should be used to assess treatment success in psoriasis (PSO). However, the DLQI does not assess the importance and achievement of treatment goals. The Patient Benefit Index (PBI) is a questionnaire that takes both into account. Currently, there is insufficient knowledge about the modulating variables of the PBI and whether it can complement the assessment of the DLQI. In a longitudinal cohort study, 82 patients with PSO were assessed before and up to sixteen weeks after a new treatment episode. The PBI was compared with patients with atopic dermatitis (AD) (n = 61). The effects of gender, age, type of therapy, improvement in body surface area (BSA), anxiety/depression, DLQI and individual coping were assessed. "Getting better skin quickly" was most important in PSO. Improved BSA, anxiety/depression, DLQI, male gender and initiation of biological therapy had the most positive effects. Partial mediation was found for the reduction of anxiety/depression and improved coping. The PBI may be considered an appropriate outcome measure of treatment success in PSO, complementing the DLQI. Patients with clinically relevant anxiety/depression and inadequate coping should be offered adjuvant psychosomatic treatment.
皮肤病生活质量指数（DLQI）应用于评估银屑病（PSO）的治疗效果。然而，DLQI并未评估治疗目标的重要性和达成情况。患者获益指数（PBI）是一种兼顾二者的调查问卷。目前，关于PBI的调节变量以及它是否能补充DLQI评估的相关知识尚不充分。在一项纵向队列研究中，对82例PSO患者在新的治疗疗程开始前及开始后长达16周进行了评估。将PBI与特应性皮炎（AD）患者（n = 61）进行比较。评估了性别、年龄、治疗类型、体表面积（BSA）改善情况、焦虑/抑郁、DLQI及个体应对方式的影响。“皮肤快速好转”在PSO中最为重要。BSA改善、焦虑/抑郁缓解、DLQI改善、男性性别及生物治疗的启动具有最积极的影响。发现焦虑/抑郁减轻和应对方式改善存在部分中介作用。PBI可被视为PSO治疗成功的一种合适的结局指标，对DLQI起到补充作用。对于有临床相关焦虑/抑郁且应对方式欠佳的患者，应提供辅助性身心治疗。
