Augustin M, Zschocke I, Lange S, Seidenglanz K, Amon U
Universitäts-Hautklinik Freiburg.
Hautarzt. 1999 Oct;50(10):715-22. doi: 10.1007/s001050051056.
Aim of the present study was a comparison of four quality of life (QoL) questionnaires in 228 patients with psoriasis (PSO, n = 148) and atopic dermatitis (AD, n = 80) regarding feasibility, discriminant validity and sensitivity to change. Evaluating were performed before and after treatment in clinic. The following questionnaires were compared. 1) Freiburg Quality of Life Assessment for Dermatoses (FLQA-d), 2) Dermatology Life Quality Index (DLQI), 3) Chronic Skin Disease Questionnaire (CSDQ) and 4) questionnaire on everyday life (ALLTAG). All questionnaires were able to discriminate significant reductions of QoL in PSO and AD, as compared to controls. In parallel to the clinical improvement, all questionnaires showed QoL improvements as well, i.e. the questionnaires were sensitive to change. However, not all of the DLQI and ALLTAG scales were sensitive to change. Also, in some cases part of the scales of these questionnaires could not be calculated due to missing data. Otherwise, all questionnaires were valid and easy to handle. Thus, QoL of patients with PSO and AD can reliably be assessed by various questionnaires. Decisive for selection are the aim and the design of the study.
本研究的目的是比较228例银屑病（PSO，n = 148）和特应性皮炎（AD，n = 80）患者的四种生活质量（QoL）问卷在可行性、区分效度和对变化的敏感性方面的差异。在诊所治疗前后进行评估。比较了以下问卷：1）皮肤病生活质量评估弗赖堡问卷（FLQA-d），2）皮肤病生活质量指数（DLQI），3）慢性皮肤病问卷（CSDQ）和4）日常生活问卷（ALLTAG）。与对照组相比，所有问卷都能区分PSO和AD患者生活质量的显著降低。与临床改善同时，所有问卷也显示生活质量有所改善，即问卷对变化敏感。然而，并非所有的DLQI和ALLTAG量表都对变化敏感。此外，在某些情况下，由于数据缺失，这些问卷的部分量表无法计算。否则，所有问卷都是有效的且易于操作。因此，PSO和AD患者的生活质量可以通过各种问卷可靠地评估。研究的目的和设计对问卷的选择起决定性作用。
