Han Tao, Long Changyou, Liu Xianwang, Zhou Fengyu, Zhang Peng, Zhang Bin, Dong Wenjie, Jing Mengyuan, Deng Liangna, Zhang Yuting, Zhou Junlin
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, 730030, China.
Second Clinical School, Lanzhou University, Lanzhou, 730000, China.
Neurosurg Rev. 2025 Jan 10;48(1):34. doi: 10.1007/s10143-025-03197-7.
To investigate the value of preoperative MRI features and ADC histogram analysis for evaluating tumor-infiltrating CD8+ T cells in meningiomas. In this single-center cross-sectional study, we conducted a retrospective analysis of clinical, imaging, and pathological data from 84 patients with meningioma and performed immunohistochemical staining to quantitatively evaluate CD8+ T cells. Using X-Tile software, we divided the patients into high-and low-CD8+ T cells groups based on cut-off values. Furthermore, we compared the clinical and MRI features between the two groups and assessed the predictive value of significant parameters by plotting ROC curves. Additionally, Spearman's analysis was used to examine the association between ADC histogram parameters and CD8+ T cells. The level of tumor-infiltrating CD8+ T cells was found to have a negative correlation with recurrence in patients with meningiomas (r=-0.235, p = 0.031). No statistically significant differences were found in clinical and conventional MRI features between the two groups (all p > 0.05). Conversely, among the ADC histogram parameters, the coefficient of variation (CV), Perc.01, Perc.05, Perc.10, and Perc.25 showed statistically significant differences between the two groups (all p < 0.05) and combined ADC histogram parameters had the highest AUC (0.791; 95%CI (0.689-0.872)). Additionally, we observed a positive correlation between Perc.01, Perc.05, Perc.10 and CD8+ T cells (p < 0.05), the CV and variance was negatively correlated with the levels of CD8+ T cells (p < 0.05). ADC histogram analysis can be used as an imaging tool to preoperatively assess CD8+ T cells in patients with meningioma, and found a certain correlation between them.
探讨术前MRI特征及表观扩散系数（ADC）直方图分析在评估脑膜瘤中肿瘤浸润性CD8+ T细胞的价值。在这项单中心横断面研究中，我们对84例脑膜瘤患者的临床、影像和病理数据进行了回顾性分析，并进行免疫组化染色以定量评估CD8+ T细胞。使用X-Tile软件，我们根据临界值将患者分为高CD8+ T细胞组和低CD8+ T细胞组。此外，我们比较了两组之间的临床和MRI特征，并通过绘制ROC曲线评估显著参数的预测价值。另外，采用Spearman分析来检验ADC直方图参数与CD8+ T细胞之间的相关性。结果发现，脑膜瘤患者中肿瘤浸润性CD8+ T细胞水平与复发呈负相关（r=-0.235，p = 0.031）。两组之间在临床和传统MRI特征方面未发现统计学显著差异（所有p>0.05）。相反，在ADC直方图参数中，变异系数（CV）、第1百分位数（Perc.01）、第5百分位数（Perc.05）、第10百分位数（Perc.10）和第25百分位数在两组之间显示出统计学显著差异（所有p<0.05），并且联合ADC直方图参数具有最高的曲线下面积（AUC）（0.791；95%可信区间（0.689 - 0.872））。此外，我们观察到Perc.01、Perc.05、Perc.10与CD8+ T细胞呈正相关（p<0.05），CV和方差与CD8+ T细胞水平呈负相关（p<0.05）。ADC直方图分析可作为一种影像学工具，术前评估脑膜瘤患者的CD8+ T细胞，并发现它们之间存在一定相关性。
