Albargawi Salma
College of Medicine, Department of Dermatology, Imam Mohammad Ibn Saud University, Riyadh, Saudi Arabia.
J Cosmet Dermatol. 2025 Jan;24(1):e16752. doi: 10.1111/jocd.16752.
Acne is a common condition observed in adolescents and in most severe acne the scars develop. There are numerous treatment options for acne scars. However, no standardized guidelines have been established to guide physicians in the optimal treatment of acne scars.
The objective of this systematic review is to evaluate the existing evidence on various fillers used for the treatment of acne scars and to compare their effectiveness with one another.
The study was designed following PRISMA guidelines, and the information was retrieved in May 2024 using the PubMed database and ClinicalTrials.gov registry. The inclusion criteria were that studies involving patients of any age or gender with acne scars of any type treated with synthetic dermal fillers, and studies published in English. The exclusion criteria were studies with less than 10 participants and studies that did not use synthetic dermal fillers. To assess the risk of bias in the included studies, the Cochrane Collaboration's Risk of Bias tool was used for randomized controlled trials, and in observational studies, the Newcastle-Ottawa Scale was used.
Twenty-six studies were included with a total of 1121 participants. Fourteen studies evaluated HA on 372 subjects, five studies focused on PMMA on 305 subjects, four on CaHA on 392 subjects, two on PLLA on 42 subjects, and one on PCL on 10 subjects.
Most of the studies included in this review were of low quality, as indicated by their scores on quality assessments, lack of high-quality RCTs, and small sample sizes. Future research should focus on conducting randomized, controlled, split-face studies with an adequate number of participants and a detailed examination of different scar subtypes.
痤疮是青少年中常见的病症，在大多数重度痤疮中会形成疤痕。痤疮疤痕有多种治疗选择。然而，尚未制定标准化指南来指导医生对痤疮疤痕进行最佳治疗。
本系统评价的目的是评估用于治疗痤疮疤痕的各种填充剂的现有证据，并比较它们彼此之间的有效性。
本研究按照PRISMA指南设计，于2024年5月使用PubMed数据库和ClinicalTrials.gov注册库检索信息。纳入标准为涉及任何年龄或性别的痤疮疤痕患者使用合成真皮填充剂治疗的研究，以及以英文发表的研究。排除标准为参与者少于10人的研究和未使用合成真皮填充剂的研究。为评估纳入研究的偏倚风险，对于随机对照试验使用Cochrane协作网偏倚风险工具，对于观察性研究使用纽卡斯尔-渥太华量表。
纳入26项研究，共1121名参与者。14项研究对372名受试者评估了透明质酸（HA），5项研究聚焦于聚甲基丙烯酸甲酯（PMMA），涉及305名受试者，4项研究对392名受试者评估了羟基磷灰石钙（CaHA），2项研究对42名受试者评估了聚左旋乳酸（PLLA），1项研究对10名受试者评估了聚己内酯（PCL）。
本评价纳入的大多数研究质量较低，这体现在其质量评估得分、缺乏高质量随机对照试验以及样本量较小。未来的研究应专注于开展有足够数量参与者的随机、对照、半脸研究，并对不同疤痕亚型进行详细检查。
