Zare Sona, Zeinali Roya, Nouri Maryam, Dehghani Abbas, Zare Solmaz, Khatib Sharin, Nilforoushzadeh Mohammad Ali
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Pars Fundamental Bio Structure Company, Sharif University of Technology, Tehran, Iran.
J Cosmet Dermatol. 2025 Sep;24(9):e70413. doi: 10.1111/jocd.70413.
Acne scars are a common side effect of acne vulgaris that can negatively impact patients' quality of life and contribute to depression and anxiety. There is no definitive treatment for this condition. Ongoing research aims to discover better therapeutic options for acne scars. This study was conducted to assess the efficacy and safety of autologous fibroblast injections with and without platelet-rich plasma (PRP) for this condition.
In this split-face pilot study, eight patients with atrophic acne scars were injected with a PRP-fibroblast suspension on one side of their face, while the other side received only PRP as a control, in three biweekly sessions. Patients were assessed before treatment and 6 months later based on biometric indices, including skin ultrasound, hydration level, skin elasticity (R2, R5, and R7), the number of pores and spots, and the acne scar's volume, area, and depth.
The median differences in skin thickness before and after follow-up were 32.57 on the treatment side and 5.33 on the control side. These changes were significantly greater on the treatment side (p-value: 0.018). Improvements in skin elasticity (p-value: 0.012), skin hydration level (p-value: 0.028), the number of fine pores (p-value: 0.043), and the volume and area of scars (p-value: 0.043) were significantly better with the combination therapy. While the number of large pores and spots also improved significantly, the extent of improvement was comparable to that observed with PRP alone.
The PRP-fibroblast suspension may be considered a novel and effective therapeutic approach for atrophic acne scars.
痤疮疤痕是寻常痤疮的常见副作用，会对患者的生活质量产生负面影响，并导致抑郁和焦虑。目前尚无针对这种情况的明确治疗方法。正在进行的研究旨在发现更好的痤疮疤痕治疗选择。本研究旨在评估自体成纤维细胞注射联合或不联合富血小板血浆（PRP）治疗痤疮疤痕的疗效和安全性。
在这项半脸试点研究中，8名萎缩性痤疮疤痕患者在面部一侧注射PRP-成纤维细胞悬液，另一侧仅注射PRP作为对照，每两周进行一次，共三次。在治疗前和6个月后，根据生物测量指标对患者进行评估，包括皮肤超声、水合水平、皮肤弹性（R2、R5和R7）、毛孔和斑点数量以及痤疮疤痕的体积、面积和深度。
随访前后皮肤厚度的中位数差异在治疗侧为32.57，在对照侧为5.33。治疗侧的这些变化明显更大（p值：0.018）。联合治疗在皮肤弹性（p值：0.012）、皮肤水合水平（p值：0.028）、细毛孔数量（p值：0.043）以及疤痕体积和面积（p值：0.043）方面的改善明显更好。虽然大毛孔和斑点数量也有显著改善，但改善程度与单独使用PRP时观察到的相当。
PRP-成纤维细胞悬液可被认为是一种治疗萎缩性痤疮疤痕的新型有效方法。
