Babolhavaeji Kiandokht, Ahmadi Amjad, Shokoohizadeh Leili
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
J Cancer Prev. 2024 Dec 30;29(4):120-128. doi: 10.15430/JCP.24.010.
Shiga toxin-producing is the most prevalent bacterial strain responsible for Shiga toxin-related infections. While Shiga toxin is inherently toxic, it has potential therapeutic applications as a component of anticancer drugs. Despite its association with infections and harmful effects on human health, Shiga toxin is being explored as a viable element in drug delivery systems targeting cancer cells. The findings indicate that the production of mutated bacteria containing Shiga toxin is an effective preventive strategy for immunization against these toxins. Furthermore, the B subunit of Shiga toxin shows promise for imaging cancer cells, opening new paths for therapeutic interventions.
产志贺毒素的细菌是导致志贺毒素相关感染的最常见菌株。虽然志贺毒素本身具有毒性，但作为抗癌药物的一个组成部分，它具有潜在的治疗应用价值。尽管它与感染有关且对人类健康有有害影响，但志贺毒素正被探索作为靶向癌细胞的药物递送系统中的一种可行元素。研究结果表明，产生含有志贺毒素的突变细菌是针对这些毒素进行免疫的有效预防策略。此外，志贺毒素的B亚基在癌细胞成像方面显示出前景，为治疗干预开辟了新途径。
