Cassell Benjamin E, Scholand Katherine, Tarter Wyatt, Hochheimer Camille J, Long Colleen, Austin Gregory L
Division of Gastroenterology and Hepatology - The University of Colorado School of Medicine; Aurora, Colorado.
Center for Innovative Design and Analysis, Colorado School of Public Health, Aurora, Colorado.
Gastro Hep Adv. 2024 Aug 23;4(1):100532. doi: 10.1016/j.gastha.2024.08.011. eCollection 2025.
The 2020 United States Multi-Society Task Force on Colorectal Cancer guidelines for surveillance after colonoscopy with polypectomy introduced significant changes in surveillance intervals. We sought to identify rates of adherence to these new guidelines at an academic medical center.
Average-risk screening colonoscopies where 1 to 4 polyps <10 mm were removed between January 1, 2020, and June 30, 2021 were included. To determine predictors of nonadherence, a multivariable logistic regression analysis was conducted and included patient and procedure-related variables. Bayesian changepoint analysis was applied to identify timing of change in adherence. Multinomial logistic regression was used to identify predictors of variability within the guidelines.
One thousand twenty-six procedures were analyzed. Adherence to the guidelines was 85%. In procedures with 1 to 2 polyps, increasing size (odds ratio [OR] 0.84 per mm; 95% confidence interval [CI]: 0.75-0.93) and a mixture of tubular adenomas (TA) and hyperplastic polyps (OR 0.35; 95% CI: 0.21-0.59) were associated with nonadherence. Among procedures with 1 to 2 TAs, age (OR 0.86 per 5-year increase; 95% CI: 0.75-0.99), increasing size (OR 0.86 per mm; 95% CI: 0.75-0.99) and polyp number (OR 0.54; 95% CI: 0.33-0.90) were associated with nonadherence. Changepoint analysis identified a potential changepoint on September 2, 2020 (95% credible interval April 2, 2020-February 22, 2020). Larger TAs were less likely to receive a 10-year recommendation (OR 0.61, 95% CI 0.5-0.75).
Adherence rates to the 2020 surveillance guidelines were high with a potential changepoint identified on 2/9/20. Deviation from guidelines was associated with patient and procedure related variables.
2020年美国多学会结直肠癌工作组关于息肉切除术后结肠镜监测的指南对监测间隔做出了重大改变。我们试图在一家学术医疗中心确定对这些新指南的遵循率。
纳入2020年1月1日至2021年6月30日期间进行的平均风险筛查结肠镜检查,这些检查切除了1至4个直径小于10毫米的息肉。为了确定不遵循的预测因素,进行了多变量逻辑回归分析,纳入了患者和手术相关变量。应用贝叶斯变点分析来确定遵循情况变化的时间点。多项逻辑回归用于确定指南内变异性的预测因素。
分析了1026例手术。对指南的遵循率为85%。在切除1至2个息肉的手术中,息肉尺寸增大(每毫米优势比[OR]0.84;95%置信区间[CI]:0.75-0.93)以及管状腺瘤(TA)和增生性息肉混合存在(OR 0.35;95% CI:0.21-0.59)与不遵循相关。在切除1至2个TA的手术中,年龄(每增加5岁OR 0.86;95% CI:0.75-0.99)、息肉尺寸增大(每毫米OR 0.86;95% CI:0.75-0.99)和息肉数量(OR 0.54;95% CI:0.33-0.90)与不遵循相关。变点分析确定了2020年9月2日的一个潜在变点(95%可信区间为2020年4月2日至2020年2月22日)。较大的TA接受10年建议的可能性较小(OR 0.61,95% CI 0.5-0.75)。
对2020年监测指南的遵循率较高,在2020年9月2日确定了一个潜在变点。与指南的偏差与患者和手术相关变量有关。