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2023年加拿大实验室接触人类病原体和毒素的监测情况

Surveillance of laboratory exposures to human pathogens and toxins, Canada, 2023.

作者信息

Nafees Abdulwadud, Gauthier Audrey, Davis Antoinette N, Tran Emily F, Abalos Christine, Girincuti Christa M, Bonti-Ankomah Samuel

机构信息

Regulatory, Operations and Emergency Management Branch, Public Health Agency of Canada, Ottawa, ON.

出版信息

Can Commun Dis Rep. 2025 Jan 2;51(1):16-25. doi: 10.14745/ccdr.v51i01a03. eCollection 2025 Jan.

Abstract

BACKGROUND

The Public Health Agency of Canada oversees the and , and monitors human pathogen and toxin incidents in licensed facilities to minimize exposure impact at the individual and population level.

OBJECTIVE

To provide an overview of confirmed laboratory exposure incidents in Canada in 2023.

METHODS

Confirmed exposure incident reports in 2023 were analyzed using R 4.2.2, Microsoft Excel and SAS.

RESULTS

In 2023, 207 incident reports were received, including 63 confirmed exposure incidents that affected 85 individuals. The academic sector accounted for 50.8% (n=32) of the reported confirmed exposure incidents. Microbiology (n=33; 52.4%) was the predominant activity being performed, with the most common occurrence types being sharps-related (n=22; 27.2%) and procedure-related (n=16; 19.8%). Human interaction (n=36; 57.1%) and standard operating procedures (n=24; 38.1%) were the most frequent root causes cited, with corrective actions often directly addressing these causes. Most of the 85 affected individuals were technicians/technologists (n=55; 64.7%) and had a median of 11 years of laboratory experience. Sixty-seven human pathogens and toxins (HPTs) were implicated in the confirmed exposure incidents, with bacteria (n=36; 53.7%) being the most common biological agent type. The median time between the incident and the reporting date was six days.

CONCLUSION

The number of confirmed exposure incidents increased in 2023 compared to 2022. Microbiology was most often the activity being performed at the time of exposure, and occurrence-types, root causes and HPTs implicated in 2023 mirrored those cited in 2022.

摘要

背景

加拿大公共卫生署负责监督[具体内容缺失],并监测持牌设施中的人类病原体和毒素事件,以尽量减少个体和群体层面的暴露影响。

目的

概述2023年加拿大已确认的实验室暴露事件。

方法

使用R 4.2.2、Microsoft Excel和SAS对2023年已确认的暴露事件报告进行分析。

结果

2023年共收到207份事件报告,其中包括63起已确认的暴露事件,涉及85人。学术部门占报告的已确认暴露事件的50.8%(n = 32)。微生物学(n = 33;52.4%)是当时进行的主要活动,最常见的发生类型是与锐器相关的(n = 22;27.2%)和与操作程序相关的(n = 16;19.8%)。人为互动(n = 36;57.1%)和标准操作程序(n = 24;38.1%)是最常被提及的根本原因,纠正措施通常直接针对这些原因。85名受影响的个体中,大多数是技术员/技术专家(n = 55;64.7%),实验室工作经验中位数为11年。67种人类病原体和毒素(HPTs)与已确认的暴露事件有关,细菌(n = 36;53.7%)是最常见的生物制剂类型。事件发生与报告日期之间的中位数时间为6天。

结论

与2022年相比,2023年已确认的暴露事件数量有所增加。微生物学是暴露时最常进行的活动,2023年涉及的发生类型、根本原因和HPTs与2022年报告的情况相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ab4/11717171/bfc7fb8e350d/510103-f1.jpg

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