El Jaouhari Maryem, Striha Megan, Edjoc Rojiemiahd, Bonti-Ankomah Samuel
Immunization Branch, Public Health Agency of Canada, Ottawa, ON.
Health Security and Regional Operations Branch, Public Health Agency of Canada, Ottawa, ON.
Can Commun Dis Rep. 2022 Jul 7;48(7-8):303-307. doi: 10.14745/ccdr.v48i78a02.
incidents that result in an exposure to human pathogens and toxins can lead to laboratory-acquired infections or intoxications (LAIs). These infections can pose a risk to the public as well, should person-to-person transmission occur outside the laboratory after an LAI. Understanding factors that contribute to exposure incidents involving LAIs may contribute to ways to mitigate future occurrences to ensure the safety of laboratory workers and the communities in which they work. This paper describes nine exposure incidents resulting in LAIs that occurred in Canada from 2016 to 2021. Of the nine cases, most affected people had both high level of education and years of experience working with pathogens. There were varying laboratory types and activities where spp. and accounted for six out of the nine cases. Procedural issues, personal protective equipment issues and sharp-related incidents were the most cited root causes. From this information, it is clear that regular training (even of experienced staff), clear and accurate standard operating procedures, proper hygiene (especially with spp. and ) and recognition of exposure incidents at the time of occurrence are important in preventing future LAIs. Only regulated laboratories working with risk group 2 or higher organisms are required to report exposures and LAIs to the Laboratory Incident Notification Canada surveillance system. Because of the small sample size, results and inferences are based on descriptive analyses only.
导致接触人类病原体和毒素的事件可能会引发实验室获得性感染或中毒（LAIs）。如果在实验室获得性感染后在实验室外发生人际传播，这些感染也会对公众构成风险。了解导致涉及实验室获得性感染的暴露事件的因素，可能有助于找到减轻未来此类事件发生的方法，以确保实验室工作人员及其工作所在社区的安全。本文描述了2016年至2021年在加拿大发生的9起导致实验室获得性感染的暴露事件。在这9起案例中，大多数受影响人员都拥有高学历且有多年处理病原体的工作经验。涉及的实验室类型和活动各不相同，其中9起案例中有6起涉及特定菌种。程序问题、个人防护装备问题和锐器相关事件是最常被提及的根本原因。从这些信息可以清楚地看出，定期培训（即使是对有经验的工作人员）、清晰准确的标准操作程序、良好的卫生习惯（尤其是针对特定菌种）以及在暴露事件发生时及时识别，对于预防未来的实验室获得性感染很重要。只有处理风险等级为2或更高生物的受监管实验室才需要向加拿大实验室事件通报监测系统报告暴露情况和实验室获得性感染。由于样本量较小，结果和推论仅基于描述性分析。
