Patel Nikhil, Ganti Latha
Orlando College of Osteopathic Medicine.
Brown University.
Orthop Rev (Pavia). 2025 Jan 6;17:127772. doi: 10.52965/001c.127772. eCollection 2025.
Osteoporosis is a degenerative bone disease that causes the weakening of bone structure. Since bone structure is dynamic throughout a person's lifespan, bones are under constant growth and destruction in a process known as bone turnover or bone remodeling. Osteoporosis involves the disruption of this growth/destruction equilibrium towards the destructive side. An increase in bone turnover leads to a lower bone density and therefore a greater risk of fracture or injury of higher severity. Bone turnover markers serve as indicators of the process of bone turnover. These markers are split into two groups: formation (building up) markers and resorption (breaking down) markers. Using biochemical techniques and assays, these markers can be measured to monitor the activity of the markers as well as determine treatment options and efficacy based on this activity. The use of biomarkers in osteoporosis can pave the way for their use in other diseases such as cancer.
骨质疏松症是一种导致骨结构变弱的退行性骨病。由于骨结构在人的一生中是动态变化的，骨骼在一个被称为骨转换或骨重塑的过程中不断生长和破坏。骨质疏松症涉及这种生长/破坏平衡向破坏一侧的失调。骨转换增加会导致骨密度降低，因此骨折或更严重损伤的风险更大。骨转换标志物是骨转换过程的指标。这些标志物分为两组：形成（构建）标志物和吸收（分解）标志物。使用生化技术和检测方法，可以测量这些标志物，以监测标志物的活性，并根据这种活性确定治疗方案和疗效。骨质疏松症中生物标志物的使用可为其在癌症等其他疾病中的应用铺平道路。
