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骨质疏松症概述与管理

An overview and management of osteoporosis.

作者信息

Sözen Tümay, Özışık Lale, Başaran Nursel Çalık

机构信息

Department of Internal Medicine, Near East University School of Medicine, Nicosia, Turkish Republic of Northern Cyprus.

Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.

出版信息

Eur J Rheumatol. 2017 Mar;4(1):46-56. doi: 10.5152/eurjrheum.2016.048. Epub 2016 Dec 30.

Abstract

Osteoporosis -related to various factors including menopause and aging- is the most common chronic metabolic bone disease, which is characterized by increased bone fragility. Although it is seen in all age groups, gender, and races, it is more common in Caucasians (white race), older people, and women. With an aging population and longer life span, osteoporosis is increasingly becoming a global epidemic. Currently, it has been estimated that more than 200 million people are suffering from osteoporosis. According to recent statistics from the International Osteoporosis Foundation, worldwide, 1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime. Every fracture is a sign of another impending one. Osteoporosis has no clinical manifestations until there is a fracture. Fractures cause important morbidity; in men, in particular, they can cause mortality. Moreover, osteoporosis results in a decreased quality of life, increased disability-adjusted life span, and big financial burden to health insurance systems of countries that are responsible for the care of such patients. With an early diagnosis of this disease before fractures occur and by assessing the bone mineral density and with early treatment, osteoporosis can be prevented. Therefore, increasing awareness among doctors, which, in turn, facilitates increase awareness of the normal populace, will be effective in preventing this epidemic.

摘要

骨质疏松症——与包括绝经和衰老在内的多种因素相关——是最常见的慢性代谢性骨病,其特征是骨脆性增加。尽管在所有年龄组、性别和种族中都有出现,但在白种人(白人种族)、老年人和女性中更为常见。随着人口老龄化和寿命延长,骨质疏松症正日益成为一种全球流行病。目前,据估计有超过2亿人患有骨质疏松症。根据国际骨质疏松症基金会最近的统计数据,在全球范围内,50岁以上的女性中有三分之一、男性中有五分之一在一生中会发生骨质疏松性骨折。每一次骨折都是另一次即将发生骨折的征兆。骨质疏松症在发生骨折之前没有临床表现。骨折会导致严重的发病率;特别是在男性中,骨折可能会导致死亡。此外,骨质疏松症会导致生活质量下降、残疾调整寿命增加,并给负责照顾此类患者的国家医疗保险系统带来巨大的经济负担。通过在骨折发生前对这种疾病进行早期诊断,并评估骨密度以及进行早期治疗,可以预防骨质疏松症。因此,提高医生的认识,进而促进普通民众的认识提高,将有效地预防这种流行病。

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本文引用的文献

1
Male Osteoporosis in the Elderly.
Int J Endocrinol. 2015;2015:907689. doi: 10.1155/2015/907689. Epub 2015 Sep 20.
2
Clinician's Guide to Prevention and Treatment of Osteoporosis.
Osteoporos Int. 2014 Oct;25(10):2359-81. doi: 10.1007/s00198-014-2794-2. Epub 2014 Aug 15.
5
The effect of three or six years of denosumab exposure in women with postmenopausal osteoporosis: results from the FREEDOM extension.
J Clin Endocrinol Metab. 2013 Nov;98(11):4483-92. doi: 10.1210/jc.2013-1597. Epub 2013 Aug 26.
8
Long-term mortality following fractures at different skeletal sites: a population-based cohort study.
Osteoporos Int. 2013 May;24(5):1689-96. doi: 10.1007/s00198-012-2225-1. Epub 2012 Dec 5.
9
Incidence of hip fracture and prevalence of osteoporosis in Turkey: the FRACTURK study.
Osteoporos Int. 2012 Mar;23(3):949-55. doi: 10.1007/s00198-011-1655-5. Epub 2011 May 19.

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