Munkwitz Stephan, Spitschan Manuel
Max-Planck-Institut für biologische Kybernetik, Tübingen.
Augenärzte Mittlerer Neckar, Praxis Stuttgart-Mitte, Stuttgart.
Z Prakt Augenheilkd Augenarztl Fortbild. 2023 Jul;44:375-378.
In addition to the rods and cones, the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGC) are responsible for encoding ambient illumination conditions. The main task of the ipRGC is to signal information about illumination to the brain. Via the retinohypothalamic pathway, light synchronises our internal biological clock and sets it to follow the environment's light-dark cycle. Light is the most important zeitgeber for our inner clock and the ipRGC are therefore highly important for the field of chronobiology. Many ocular and retinal functions also follow a diurnal rhythm. Chrono-ophthalmology is an emerging research field at the interface between the eye and the clock.
除了视杆细胞和视锥细胞外，含黑视蛋白的内在光敏视网膜神经节细胞（ipRGC）负责编码环境光照条件。ipRGC的主要任务是向大脑传递有关光照的信息。通过视网膜下丘脑通路，光线使我们的内部生物钟同步，并使其遵循环境的昼夜循环。光线是我们内部生物钟最重要的授时因子，因此ipRGC在时间生物学领域非常重要。许多眼部和视网膜功能也遵循昼夜节律。时辰眼科学是一个新兴的研究领域，处于眼睛和生物钟的交叉点。
