Whiteley Jennifer, Shan Hongchao, Yeung Jonathan C
Toronto Lung Transplant Program, Toronto General Hospital, Toronto, Canada.
Ann Thorac Surg Short Rep. 2024 Jun 28;2(4):848-850. doi: 10.1016/j.atssr.2024.06.013. eCollection 2024 Dec.
Ex vivo lung perfusion (EVLP) is used to evaluate donor lungs prior to lung transplantation. Development of pulmonary edema during EVLP is generally thought to represent inflammatory breakdown of the air-fluid barrier and these lungs are declined for transplant. We present the case of a donor lung that underwent stapled wedge resection during cold storage for air leak and the subsequent development of profound (∼650 mL) pulmonary edema around the staple line during EVLP. Nevertheless, the edema cleared shortly after implantation. This report illustrates the potential for significant alveolar fluid clearance and sealing of vascular injury after implantation when edema is not caused by inflammatory injury.
体外肺灌注（EVLP）用于在肺移植前评估供体肺。一般认为，EVLP期间肺水肿的发生代表气液屏障的炎症性破坏，这些肺会被拒绝用于移植。我们报告了一例供体肺的病例，该供体肺在冷藏期间因漏气接受了吻合器楔形切除术，随后在EVLP期间吻合线周围出现了严重（约650毫升）的肺水肿。然而，水肿在植入后不久就消退了。本报告说明了当水肿不是由炎症损伤引起时，植入后肺泡液显著清除和血管损伤封闭的可能性。
