Suri Himanshi, Senghor K A Arul, Vinodhini V M, Sai Koneru T, Charles Jonathan, Rooban S
Medical Undergraduate, Department of General Medicine, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India.
Department of Biochemistry, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India.
J Family Med Prim Care. 2024 Dec;13(12):5662-5666. doi: 10.4103/jfmpc.jfmpc_611_24. Epub 2024 Dec 9.
Vitamin B is an essential micronutrient, aids in synthesis of neurotransmitters, and vital for cognitive function. In the current younger population with more of electronic gadgets and scientific world seems to slow down critical thinking and impairs the trick of comprehensive subjective learning. Vitamin B deficiency has been linked to insulin-resistant state and future cardiovascular risk.
This study compared single-point insulin sensitivity estimator (SPISE) index, cognitive performance, and CVS risk in vitamin B-adequate and -deficient young adults.
Study participants were 60 young female participants, 18 to 35 years with the inclusion criteria of BMI more than 22.9 and waist circumference >85 cm. Anthropometric variables were measured. Lipid profile analytes were analyzed in an integrated Beckman Coulter AU series autoanalyzer. Based on SPISE index categorized as insulin resistant Group A <5.82 and non-insulin resistant Group B ≥5.82. Cognitive function was assessed based on Mini-Mental State Examination screening tool.
Analytical cross-sectional study.
Individuals with low vitamin B levels had a low SPISE index of less than 5.82 and low HDL-C levels, which indicates abnormal lipidemia and reduced insulin sensitivity. Mini-Mental State Examination was low in B-deficient. B revealed positive correlation with MMSE, SPISE Index, and HDLc, whereas negative correlation with TGL and TGL/HDLc ratio.
Individuals with low vitamin B levels express low SPISE index, and low performance on MMSE confirms risk of impairment of cognitive function and cardiovascular risk.
维生素B是一种必需的微量营养素，有助于神经递质的合成，对认知功能至关重要。在当前使用更多电子设备的年轻人群中，科学世界似乎减缓了批判性思维，并损害了综合主观学习的能力。维生素B缺乏与胰岛素抵抗状态及未来心血管风险有关。
本研究比较了维生素B充足和缺乏的年轻成年人的单点胰岛素敏感性估计值（SPISE）指数、认知表现和心血管风险。
研究参与者为60名18至35岁的年轻女性，纳入标准为BMI超过22.9且腰围>85厘米。测量人体测量变量。在集成的贝克曼库尔特AU系列自动分析仪中分析血脂分析物。根据SPISE指数分为胰岛素抵抗组A<5.82和非胰岛素抵抗组B≥5.82。基于简易精神状态检查表筛查工具评估认知功能。
分析性横断面研究。
维生素B水平低的个体SPISE指数低于5.82且高密度脂蛋白胆固醇（HDL-C）水平低，这表明血脂异常和胰岛素敏感性降低。维生素B缺乏者的简易精神状态检查表得分较低。维生素B与简易精神状态检查表、SPISE指数和HDLc呈正相关，而与甘油三酯（TGL）和TGL/HDLc比值呈负相关。
维生素B水平低的个体SPISE指数低，简易精神状态检查表表现不佳证实了认知功能受损和心血管风险。
