Sun Yangbo, Sun Minxian, Liu Buyun, Du Yang, Rong Shuang, Xu Guifeng, Snetselaar Linda G, Bao Wei
Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States.
Department of Endocrinology, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Endocrinol (Lausanne). 2019 Jun 27;10:414. doi: 10.3389/fendo.2019.00414. eCollection 2019.
Several studies have suggested that vitamin B12 deficiency is more common in obese individuals. We evaluated the cross-sectional associations of serum vitamin B12 concentrations with obesity in a nationally representative sample of adults in the United States. We included 9,075 participants aged ≥20 years in the National Health and Nutrition Examination Survey 2011-2014. Serum vitamin B12 concentrations were measured by electrochemiluminescence immunoassay. Obesity was defined as BMI ≥30 kg/m. We used logistic regression with sample weights to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Serum vitamin B12 concentrations were lower among obese adults compared with non-obese adults. After adjustment for age, gender, race/ethnicity, socioeconomic status, dietary and lifestyle factors, use of medications that could affect the serum vitamin B12 levels, dietary supplement use and fasting time, the multivariable-adjusted ORs (95% CIs) of obesity were 1.00 (reference), 0.95 (0.79, 1.14), 0.86 (0.74, 0.99), and 0.71 (0.60, 0.84) ( for trend <0.001) for increasing quartiles of serum vitamin B12 concentrations. In a large nationally representative sample of U.S. adults, higher serum vitamin B12 levels were inversely associated with obesity. Further investigation is needed to understand the underlying mechanisms.
多项研究表明，维生素B12缺乏在肥胖个体中更为常见。我们在美国成年人的全国代表性样本中评估了血清维生素B12浓度与肥胖的横断面关联。我们纳入了2011 - 2014年国家健康和营养检查调查中9075名年龄≥20岁的参与者。血清维生素B12浓度通过电化学发光免疫测定法测量。肥胖定义为BMI≥30kg/m²。我们使用带样本权重的逻辑回归来估计比值比（OR）和95%置信区间（CI）。与非肥胖成年人相比，肥胖成年人的血清维生素B12浓度较低。在调整了年龄、性别、种族/民族、社会经济地位、饮食和生活方式因素、可能影响血清维生素B12水平的药物使用、膳食补充剂使用和禁食时间后，随着血清维生素B12浓度四分位数的增加，肥胖的多变量调整OR（95%CI）分别为1.00（参考值）、0.95（0.79，1.14）、0.86（0.74，0.99）和0.71（0.60，0.84）（趋势<0.001）。在一个大型美国成年人全国代表性样本中血清维生素B12水平较高与肥胖呈负相关。需要进一步调查以了解潜在机制。
