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智力残疾中的社会人口学因素与近亲结婚:一项试点研究。

Sociodemographic Factors and Consanguinity in Intellectual Disability: A Pilot Study.

作者信息

Benmakhlouf Yousra, Laghmich Achraf, Ben Makhlouf Kaoutar, Barakat Amina, Ghailani Nourouti Naima, Bennani Mechita Mohcine

机构信息

All authors are with Intelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University in Tangier, Morocco.

出版信息

Innov Clin Neurosci. 2024 Dec 1;21(10):9-14. eCollection 2024 Oct-Dec.

PMID:39790896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11709441/
Abstract

OBJECTIVE

Arab populations have a long tradition of consanguinity. In Morocco, consanguineous marriages are culturally favored. In this study, we assessed the effect of consanguinity on the occurrence of intellectual disability (ID) and investigated its association to education level and professional status in a series of Moroccan families.

DESIGN

In total, 186 patients with ID were included in this study. Data were processed and analyzed with the IBM SPSS.

RESULTS

The rate of consanguinity among the parents of children with ID was 34.95 percent. Marriages between first cousins accounted for 24.19 percent of consanguineous unions (FI=0.02). In the general population (n=300), 27.3 percent of marriages were consanguineous, with 22.66 percent being marriages between first cousins. Marriage between first cousins was the most common type of consanguineous marriage. The illiteracy rate was greater among women, compared to men (56.9% vs. 37.87%). The majority of mothers (81.11%) were housewives. A predominance of low professional status was observed among the men (62.22% of population, 22.7%). There was a high correlation between consanguinity and ID. The association between education level, professional status, and consanguinity rate in ID was not statistically significant (>0.05).

CONCLUSION

The consanguinity rate in Moroccan families remains important. More strategies and efforts must be taken and reinforced for a better understanding and awareness of consanguinity risks to significantly reduce this practice.

摘要

目的

阿拉伯人群有着悠久的近亲结婚传统。在摩洛哥,近亲婚姻在文化上受到青睐。在本研究中,我们评估了近亲结婚对智力残疾(ID)发生率的影响,并在一系列摩洛哥家庭中调查了其与教育水平和职业地位的关联。

设计

本研究共纳入186例智力残疾患者。数据采用IBM SPSS进行处理和分析。

结果

智力残疾儿童父母的近亲结婚率为34.95%。表亲之间的婚姻占近亲结合的24.19%(亲缘系数=0.02)。在普通人群(n = 300)中,27.3%的婚姻为近亲婚姻,其中22.66%为表亲之间的婚姻。表亲之间的婚姻是最常见的近亲婚姻类型。女性的文盲率高于男性(56.9%对37.87%)。大多数母亲(81.11%)是家庭主妇。男性中职业地位低的占多数(占人口的62.22%,22.7%)。近亲结婚与智力残疾之间存在高度相关性。智力残疾人群中教育水平、职业地位和近亲结婚率之间的关联无统计学意义(>0.05)。

结论

摩洛哥家庭的近亲结婚率仍然很高。必须采取并加强更多策略和努力,以更好地理解和认识近亲结婚的风险,从而显著减少这种做法。

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本文引用的文献

1
Intellectual Disability in Morocco: A Pilot Study.摩洛哥的智力残疾:一项试点研究。
Innov Clin Neurosci. 2020 Oct 1;17(10-12):9-13. eCollection 2020 Oct-Dec.
2
Screening of the duplication 24 pb of ARX gene in Moroccan patients with X-linked Intellectual Disability.筛查 24 pb 的 ARX 基因在摩洛哥患者与 X 连锁的智力残疾。
BMC Res Notes. 2021 Mar 23;14(1):110. doi: 10.1186/s13104-021-05526-7.
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Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study.摩洛哥北部的血红蛋白病:近亲婚配的初步研究。
Biomed Res Int. 2019 Sep 26;2019:6857417. doi: 10.1155/2019/6857417. eCollection 2019.
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Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum.北非的α-地中海贫血:流行情况与分子谱。
Biomed Res Int. 2019 Mar 13;2019:2080352. doi: 10.1155/2019/2080352. eCollection 2019.
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Effect of inbreeding on intellectual disability revisited by trio sequencing.采用三联体测序技术重新研究近交对智力障碍的影响。
Clin Genet. 2019 Jan;95(1):151-159. doi: 10.1111/cge.13463. Epub 2018 Nov 19.
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Genetics of intellectual disability in consanguineous families.近亲家庭智力残疾的遗传学研究。
Mol Psychiatry. 2019 Jul;24(7):1027-1039. doi: 10.1038/s41380-017-0012-2. Epub 2018 Jan 4.
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Genetics of consanguinity and inbreeding in health and disease.近亲结婚与近亲繁殖在健康与疾病中的遗传学
Ann Hum Biol. 2017 Mar;44(2):99-107. doi: 10.1080/03014460.2016.1265148. Epub 2016 Dec 14.
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