Lakhan Ram, Bipeta Rajshekhar, Yerramilli Srinivasa S R R, Nahar Vinayak K
Department of Health and Human Performance, Berea College, Berea, Kentucky, USA.
Consultant Psychiatrist, Rajasri Clinic, Hyderabad, Telangana, India.
J Neurosci Rural Pract. 2017 Oct-Dec;8(4):551-555. doi: 10.4103/jnrp.jnrp_104_17.
Intellectual disability (ID) can be inherited in families through consanguineous marriage. The ID in an individual can be associated with the ID, epilepsy, and mental illness in their parents. Such connections can be seen more closely among consanguineous marriages in tribal and nontribal population in India.
This study shows a few common patterns of the consanguineous relationship in the parents of children with ID in India.
This is a case series research design. Extreme or deviant case sampling was applied. Data were collected in homes, camps, and clinical settings in the Barwani district of Madhya Pradesh, India. The patterns of consanguineous marriages and the relationship between children with ID and their relatives with ID, epilepsy, and mental illness were analyzed and reported with pedigree charts.
Multiple patterns of consanguineous marriages in tribal and nontribal populations were observed. ID was found to be associated in children with their relatives of the first, second, and third generations.
ID may inherit in individuals from their relatives of the first, second, and third generations who have ID, epilepsy, or mental illness and married in the relationship. Appropriate knowledge, guidance, and counseling may be provided to potential couples before planning a consanguineous marriage.
智力残疾（ID）可通过近亲结婚在家族中遗传。个体的智力残疾可能与其父母的智力残疾、癫痫和精神疾病有关。在印度部落和非部落人群的近亲婚姻中，这种关联更为明显。
本研究展示了印度智力残疾儿童父母中近亲关系的一些常见模式。
这是一项病例系列研究设计。采用极端或偏差病例抽样。在印度中央邦巴尔瓦尼区的家庭、营地和临床环境中收集数据。用系谱图分析并报告近亲婚姻模式以及智力残疾儿童与其患有智力残疾、癫痫和精神疾病的亲属之间的关系。
观察到部落和非部落人群中多种近亲婚姻模式。发现智力残疾儿童与其第一代、第二代和第三代亲属有关联。
智力残疾可能从患有智力残疾、癫痫或精神疾病且以近亲关系结婚的第一代、第二代和第三代亲属遗传给个体。在计划近亲婚姻之前，可为潜在夫妇提供适当的知识、指导和咨询。
