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美沙酮治疗阿片类物质使用障碍的患者使用挑战及改善居家给药安全性与便利性的解决方案观点

Patient Challenges in Utilization of Methadone to Treat Opioid Use Disorder and Perspectives on a Solution for Improved Security and Convenience in Take-home Dosing.

作者信息

Morse Eric, Christianson Graeme, Olivadoti Melissa, Timberlake John

机构信息

Dr. Morse is with Carolina Performance in Raleigh, North Carolina and Morse Clinics in Raleigh, North Carolina.

Mr. Christianson is with 4C Research Group in Somerton, United Kingdom.

出版信息

Innov Clin Neurosci. 2024 Dec 1;21(10):25-33. eCollection 2024 Oct-Dec.

Abstract

BACKGROUND

Methadone is commonly utilized to treat opioid use disorder (OUD). Requirements to visit an opioid treatment provider (OTP) clinic for methadone treatment limits access to treatment, impacts quality of life, and reduces OUD treatment program retention. The Computerized Oral Prescription Administration (COPA) system is a dual-biometric dispensing device for take-home dosing that could reduce the impacts of methadone administration on patients and clinic staff.

OBJECTIVE

To identify challenges for patients treated with methadone for OUD and gain their perspectives on COPA.

METHODS

Adult patients treated with methadone at a single-site OTP clinic were recruited to complete a qualitative interview regarding their experience with methadone and the impact that expansion of take-home doses would have on their life. Participants were provided printed resources describing COPA and handled a COPA device before being asked for their perspectives.

RESULTS

Participants (n=12) were 58.33 percent male and 41.67 percent female, and had no take-home doses (n=5), 2 to 5 days of take-home doses (n=4), or six or more days of take-home doses (n=3). Most (91.67%) participants desired more take-home doses, and 66.7 percent stated more take-home doses would reduce the negative impact of OUD treatment on their ability to work. Average time and cost per trip to obtain their methadone dose at the clinic was 75 minutes and $36.58, respectively. Participants responded positively toward COPA. Participants with no take-home privileges would pay $126.88 per month to obtain take-home privileges by using COPA, and those with take-home privileges would pay $30.31 per month to keep the same level of take-home doses and $117.50 per month to expand their take-home doses using COPA.

CONCLUSION

Participants endured a monetary and time burden to access their methadone treatment, and wished to have more take-home doses to reduce the frequency of their visits to the OTP clinic. Participants viewed take-home doses as having a positive impact on their ability to care for family members, hold a job, and travel, and they appreciated the key attributes of COPA and were willing to invest their own funds to gain access to the device. COPA is a potential solution to expand take-home methadone access to patients while ensuring safety, adherence, retention, and appropriate use.

摘要

背景

美沙酮常用于治疗阿片类物质使用障碍(OUD)。前往阿片类物质治疗机构(OTP)诊所接受美沙酮治疗的要求限制了治疗的可及性,影响生活质量,并降低了OUD治疗项目的留存率。计算机化口服处方给药(COPA)系统是一种用于家庭给药的双生物识别配药设备,可减少美沙酮给药对患者和诊所工作人员的影响。

目的

确定接受美沙酮治疗OUD的患者所面临的挑战,并了解他们对COPA的看法。

方法

招募在单一地点的OTP诊所接受美沙酮治疗的成年患者,就其美沙酮治疗经历以及扩大家庭给药剂量对其生活的影响完成一次定性访谈。在询问参与者的看法之前,为他们提供了描述COPA的印刷资料,并让他们操作了COPA设备。

结果

参与者(n = 12)中男性占58.33%,女性占41.67%,且有未接受家庭给药的(n = 5)、接受2至5天家庭给药的(n = 4)或接受6天及以上家庭给药的(n = 3)。大多数(91.67%)参与者希望增加家庭给药剂量,66.7%的参与者表示更多的家庭给药剂量将减少OUD治疗对其工作能力的负面影响。在诊所获取美沙酮剂量每次的平均时间和费用分别为75分钟和36.58美元。参与者对COPA反应积极。没有家庭给药特权的参与者愿意每月支付126.88美元,通过使用COPA获得家庭给药特权,而有家庭给药特权的参与者愿意每月支付30.31美元以维持相同水平的家庭给药剂量,以及每月支付117.50美元以使用COPA扩大其家庭给药剂量。

结论

参与者为获得美沙酮治疗承受了金钱和时间负担,并希望增加家庭给药剂量以减少前往OTP诊所的频率。参与者认为家庭给药剂量对他们照顾家庭成员、保住工作和出行的能力有积极影响,他们赞赏COPA的关键特性,并愿意投入自己的资金以获得使用该设备的机会。COPA是一种潜在的解决方案,可在确保安全、依从性、留存率和合理使用的同时,扩大患者获得家庭美沙酮给药的机会。

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