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作为抗癌剂的吡唑啉及其衍生物:合成与生物活性:综述

Pyrazoline and Pyrazoline Derivatives as Anti-Cancer Agents: Synthesis and Biological Activities: A Compressive Review.

作者信息

Ray Pushkar Kumar, Sharma Ruchi, Kumar Abhishek

机构信息

Department of Pharmacy, Harlal Institute of Management and Technology (HIMT), Plot no-8, knowledge park-1, Greater Noida, Uttar Pradesh -201310, India.

出版信息

Curr Top Med Chem. 2025;25(13):1548-1612. doi: 10.2174/0115680266339816241212081205.

Abstract

BACKGROUND

A heterocyclic molecule containing five rings, three carbon atoms, two nitrogen atoms, and a single endocyclic bond is called pyrazoline. Because of its intriguing electrical characteristics and potential for dynamic applications, pyrazoline is one type of electron-rich nitrogen carrier that is becoming more and more popular. This study synthesizes pyrazoline derivatives using a variety of techniques to demonstrate a highly biological function.

OBJECTIVE

Pharmaceutical chemistry has found the study of the biological activity of pyrazoline derivatives to be an interesting field. Pyrazolines find utility in numerous multipurpose applications. It has been discussed to examine the current study of patent literature on pyrazoline derivatives (2000-2024) that describes the introduction, general approach, synthesis scheme Structureactivity and relationship, marketed drug, and patents on anticancer activities.

CONCLUSION

A recognized heterocyclic chemical is pyrazolines. Three carbon atoms and two adjacent nitrogen atoms make up the five-membered ring that is pyrazoline. A variety of methods are available to determine its synthesis. Extensive studies have been conducted in this field since it has been found that many pyrazoline derivatives have a crucial biological effect on anticancer activity. The application of pyrazoline as an anticancer agent is a fascinating moiety with a wealth of potential applications for further research by scientists.

摘要

背景

含有五个环、三个碳原子、两个氮原子和一个单内环键的杂环分子称为吡唑啉。由于其引人入胜的电学特性和动态应用潜力,吡唑啉是一种越来越受欢迎的富电子氮载体。本研究使用多种技术合成吡唑啉衍生物,以证明其具有高度的生物学功能。

目的

药物化学发现对吡唑啉衍生物的生物活性研究是一个有趣的领域。吡唑啉在众多多功能应用中有用途。本文讨论了对2000年至2024年关于吡唑啉衍生物的专利文献的当前研究,这些文献描述了其介绍、一般方法、合成方案、构效关系、上市药物以及抗癌活性方面的专利。

结论

吡唑啉是一种公认的杂环化合物。吡唑啉由三个碳原子和两个相邻的氮原子组成五元环。有多种方法可用于确定其合成。自从发现许多吡唑啉衍生物对抗癌活性具有关键的生物学作用以来,该领域已经进行了广泛的研究。吡唑啉作为抗癌剂的应用是一个引人入胜的部分,具有丰富的潜在应用,可供科学家进一步研究。

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