Montanino Concetta, Farinella Federica, De Felice Bruna, Del Buono Andrea, D'Orta Armando
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, 81100, Italy.
DDR Research Clinic, Caserta, Italy.
Endocr Metab Immune Disord Drug Targets. 2025 Jan 8. doi: 10.2174/0118715303329562241116045410.
Curcumin is a polyphenolic compound derived from the food spice turmeric that has received interest from the medical and scientific world for its role in the management of several conditions. Clinical studies, in humans, have shown that ingested Curcumin is safe even at high doses (12 g/day), but it has poor bioavailability primarily due to poor absorption and rapid metabolism and elimination. Several strategies have been implemented to improve the bioavailability of Curcumin, for example, the combination of piperine in a complex with Curcumin, or the usage of formulations with phospholipid or liposomal complexes.
The present work aims to explore and compare the systemic anti-inflammatory effects of two different types of Curcumin: a traditional fat-soluble formulation (95% Curcumin) and an innovative standardized reconstituted water-soluble one (Curcuin), made in micelles in aqueous solution.
Research was conducted on 30 patients, 15 patients were treated with turmeric (Curcuma longa L., rhizome) dried extract titled 95% Curcumin (Curcumin 425mg/day) conjugated with piperine, and 15 patients were treated with Curcumin (turmeric 286 mg dried extract titled 35%; Curcuminoids 100 mg/day, standardized water-soluble) made in micelles in highly absorbed aqueous solution. We considered the quantitative variations of laboratory parameters: Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), Ferritin (24 to 336 ng/mL for adult males), and cholesterol LDL.
Patients treated with dried extract titled 95% Curcumin, for 90 days, show a lower value of ESR, CRP, Ferritin, and LDL cholesterol compared with the same laboratory parameters before the introduction of Curcumin into the diet. Also, patients treated with Curcuin report a lower value of ESR, CRP, Ferritin, and LDL cholesterol after the introduction of turmeric dried extract in the diet, but with a major significance compared with those obtained with 95% Curcumin conjugated with piperine.
As we had hypothesized, both turmeric-derived extracts have successfully reduced ESR, CRP, Ferritin, and cholesterol LDL values, exerting an anti-inflammatory action and anti-cholesterolemic action. These results suggest a possible use of Curcumin and in particular Curcuin as a coadjuvant for the treatment of inflammatory disease and to decrease cholesterol levels. However, additional investigation is needed to resolve doubts regarding Curcumin dosage form, dose, and medication frequency.
姜黄素是一种从食用香料姜黄中提取的多酚类化合物，因其在多种疾病治疗中的作用而受到医学界和科学界的关注。人体临床研究表明，即使高剂量（12克/天）摄入姜黄素也是安全的，但其生物利用度较差，主要原因是吸收不良以及快速代谢和消除。已实施多种策略来提高姜黄素的生物利用度，例如，将胡椒碱与姜黄素制成复合物，或使用含有磷脂或脂质体复合物的制剂。
本研究旨在探索和比较两种不同类型姜黄素的全身抗炎作用：一种传统的脂溶性制剂（95%姜黄素）和一种创新的标准化复溶水溶性制剂（Curcuin），后者在水溶液中制成胶束。
对30名患者进行研究，15名患者接受名为95%姜黄素（425毫克/天姜黄素）的姜黄（姜黄属植物姜黄的根茎）干燥提取物与胡椒碱的联合治疗，15名患者接受在高吸收性水溶液中制成胶束的姜黄素（名为35%的286毫克姜黄干燥提取物；100毫克/天姜黄素类化合物，标准化水溶性）治疗。我们考虑了实验室参数的定量变化：红细胞沉降率（ESR）、C反应蛋白（CRP）、铁蛋白（成年男性为24至336纳克/毫升）和胆固醇低密度脂蛋白。
接受名为95%姜黄素干燥提取物治疗90天的患者，与饮食中引入姜黄素之前的相同实验室参数相比，ESR、CRP、铁蛋白和低密度脂蛋白胆固醇的值较低。此外，接受Curcuin治疗的患者在饮食中引入姜黄干燥提取物后，ESR、CRP、铁蛋白和低密度脂蛋白胆固醇的值也较低，但与95%姜黄素与胡椒碱联合治疗所获得的值相比，具有更显著的意义。
正如我们所假设的，两种姜黄提取物均成功降低了ESR、CRP、铁蛋白和胆固醇低密度脂蛋白的值，发挥了抗炎作用和抗胆固醇作用。这些结果表明，姜黄素尤其是Curcuin可能作为辅助药物用于治疗炎症性疾病和降低胆固醇水平。然而，需要进一步研究以解决关于姜黄素剂型、剂量和用药频率的疑问。
