Ferreira-Hermosillo Aldo, Santana-Sánchez Paola, Vaquero-García Ricardo, García-Sáenz Manuel R, Castro-Ríos Angélica, Chávez-Rueda Adriana K, Gómez-Díaz Rita A, Chávez-Sánchez Luis, Legorreta-Haquet María V
Unidad de Investigación en Enfermedades Endócrinas de la UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Unidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Cells. 2025 Jan 4;14(1):48. doi: 10.3390/cells14010048.
Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. Additionally, PD1 appears to play a significant role in T1D. Notably, PRL levels correlate with an earlier disease onset and a specific T cell phenotype, hinting at the potential influence of PRL. These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies.
1型糖尿病（T1D）是一种复杂的疾病，由免疫系统攻击胰腺中产生胰岛素的β细胞所致。了解不同T细胞亚群在T1D发生和发展中的作用至关重要。通过使用流式细胞术比较T细胞的特征，我们可以确定治疗反应或治疗无效的潜在指标。我们的研究揭示了T1D患者催乳素（PRL）水平升高，同时关键细胞因子的产生减少。此外，PD1似乎在T1D中起重要作用。值得注意的是，PRL水平与疾病较早发作和特定T细胞表型相关，这暗示了PRL的潜在影响。这些发现凸显了进一步研究的必要性，以确定有前景的细胞靶点，用于更有效和个性化的治疗。
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